Using the developed process, more than 30 pilot-plant and commercial manufacturing scale batches of palbociclib have
been manufactured with a D(50) particle size in the range of 12.14 μm.
Using the developed process, more than 30 pilot-plant and commercial manufacturing scale batches of palbociclib have
been manufactured with a D(50) particle size in the range of 12-14 μm.
国内已经申报成功的粒径控范围也不能参考，还是要参考原研。可以看下这片文章：Palbociclib Commercial Manufacturing Process Development. Part III. Deprotection Followed by Crystallization for API Particle Property Control，
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恕我直言 已经申报的具体内容，是不会告诉你的 也是不公开的
Using the developed process, more than 30 pilot-plant and commercial manufacturing scale batches of palbociclib have
been manufactured with a D(50) particle size in the range of 12.14 μm.
Using the developed process, more than 30 pilot-plant and commercial manufacturing scale batches of palbociclib have
been manufactured with a D(50) particle size in the range of 12-14 μm.
国内已经申报成功的粒径控范围也不能参考，还是要参考原研。可以看下这片文章：Palbociclib Commercial Manufacturing Process Development. Part III. Deprotection Followed by Crystallization for API Particle Property Control，