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高天上圣

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[求助] 有一个审稿意见看不懂 已有1人参与

各位高手,我投了一篇文章,审稿意见给了一句:Throughout the study, please clarify whether the number of zinc ions bound to the six zinc finger proteins of MTF-1 changes, rather than the number of zinc finger proteins themselves.- this was only done in the abstract
请大家看看我的摘要哪里需要改动,怎么改?本人英语不好
摘要:
Metal ion homeostasis and heavy metal detoxifica-
tion systems are regulated by certain genes associated with
metal ion transport. Metallothionein (MT) and metal response
element binding transcription factor 1 (MTF-1) are important
regulatory proteins involved in the mediation of intracellular
metal ion balance. Differences in the zinc-binding affinities
of the zinc fingers of MTF-1 and the α- and β-domains of MT
facilitate their regulation of Zn2+ concentration. Alterations in
the intracellular concentration of Zn2+ influence the MTF-1
zinc finger number, and MTF-1 containing certain zinc finger
numbers  regulates  the  expression  of  corresponding  target
genes. The present review evaluates the association between
zinc finger number in MTF‑1 protein, MTF-1 target genes and
the mechanism underlying MT regulation of the zinc finger
number in MTF-1.
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高天上圣

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3楼: Originally posted by guoliwang at 2014-11-16 16:18:20
是啊,关键是Differences in the zinc-binding affinities of the zinc fingers 的意思是每个锌指结合锌离子的能力改变了。而审稿的意思是你的文中只提到蛋白的锌指结构数目增加了。...

4楼2014-11-16 16:32:06
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自私的猫1988

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高天上圣: 金币+5, ★★★★★最佳答案 2014-11-16 16:31:41
你在摘要中提到了【Differences in the zinc-binding affinities of the zinc fingers of MTF-1】 and the α- and β-domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intracellular concentration of Zn2+ influence the MTF-1 zinc finger number, and MTF-1 containing certain zinc finger numbers  regulates  the  expression  of  corresponding  target genes.
编辑让你澄清问题,是Zn离子结合数量而不是锌指蛋白数量发生了变化,摘要里面说明了,文中没有,确认一下
2楼2014-11-16 15:26:16
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guoliwang

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2楼: Originally posted by 自私的猫1988 at 2014-11-16 15:26:16
你在摘要中提到了【Differences in the zinc-binding affinities of the zinc fingers of MTF-1】 and the α- and β-domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intr ...

是啊,关键是Differences in the zinc-binding affinities of the zinc fingers 的意思是每个锌指结合锌离子的能力改变了。而审稿的意思是你的文中只提到蛋白的锌指结构数目增加了。

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3楼2014-11-16 16:18:20
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