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¸÷λ¸ßÊÖ£¬ÎÒͶÁËһƪÎÄÕ£¬Éó¸åÒâ¼û¸øÁËÒ»¾ä£ºThroughout the study, please clarify whether the number of zinc ions bound to the six zinc finger proteins of MTF-1 changes, rather than the number of zinc finger proteins themselves.- this was only done in the abstract
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Metal ion homeostasis and heavy metal detoxifica-
tion systems are regulated by certain genes associated with
metal ion transport. Metallothionein (MT) and metal response
element binding transcription factor 1 (MTF-1) are important
regulatory proteins involved in the mediation of intracellular
metal ion balance. Differences in the zinc-binding affinities
of the zinc fingers of MTF-1 and the ¦Á- and ¦Â-domains of MT
facilitate their regulation of Zn2+ concentration. Alterations in
the intracellular concentration of Zn2+ influence the MTF-1
zinc finger number, and MTF-1 containing certain zinc finger
numbers  regulates  the  expression  of  corresponding  target
genes. The present review evaluates the association between
zinc finger number in MTF‑1 protein, MTF-1 target genes and
the mechanism underlying MT regulation of the zinc finger
number in MTF-1.
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guoliwang

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2Â¥: Originally posted by ×Ô˽µÄè1988 at 2014-11-16 15:26:16
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ÄãÔÚÕªÒªÖÐÌáµ½ÁË¡¾Differences in the zinc-binding affinities of the zinc fingers of MTF-1¡¿ and the ¦Á- and ¦Â-domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intracellular concentration of Zn2+ influence the MTF-1 zinc finger number, and MTF-1 containing certain zinc finger numbers  regulates  the  expression  of  corresponding  target genes.
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ÒýÓûØÌû:
3Â¥: Originally posted by guoliwang at 2014-11-16 16:18:20
Êǰ¡£¬¹Ø¼üÊÇDifferences in the zinc-binding affinities of the zinc fingers µÄÒâ˼ÊÇÿ¸öпָ½áºÏпÀë×ÓµÄÄÜÁ¦¸Ä±äÁË¡£¶øÉó¸åµÄÒâ˼ÊÇÄãµÄÎÄÖÐÖ»Ìáµ½µ°°×µÄпָ½á¹¹ÊýÄ¿Ôö¼ÓÁË¡£...

4Â¥2014-11-16 16:32:06
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