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| Sacrifice the rats at the predetermined time after adminstration by vein injection in the tail. Harvest organs and smash them in the homogenizer. Seperate proteins from the homogenate and then determine concentration of the test substance using LC-MS/MS method. |
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| Kill the rat after injecting through tail vein at time point. Take out each tissue and homogenate respectively, make the protein precipitate. Detect drug concentration in each tissue with analytical method of LC-MS/MS. |
2Â¥2013-07-26 16:09:53
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5Â¥2013-07-28 11:10:32













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