一段操作摘要，是TFA脱BOC然后成环的，参考一下：
A was dissolved in DCM (250mL) and TFA (250mL) and stirred for 1h at ambient temperature. The mixture was evaporated to dryness and the residue dissolved in DCM (300mL), washed with 10% aqueous K2CO3 (2 × 200mL), and dried (MgSO4). Filtration and evaporation of the solvent and crystallisation of the residue from 2-propanol afforded B
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三氟乙酸，我用水泵40度就拉出来了啊
然后用水洗，碳酸氢钠洗，氯化钠洗不就可以了啊
楼上方法不错 一般我也这么做
但是如果你的胺溶与水的话 就比较麻烦了
那样最好先用少量水滴加进去 然后加入固体ＮＡＣＯ３ 再用ＴＨＦ 溶解中和后的产物 ，过滤
滤液旋干 ＣＨ２ＣＬ２溶解 过滤 旋干
[ Last edited by 风吹叶儿落 on 2008-12-31 at 00:50 ]
一段操作摘要，是TFA脱BOC然后成环的，参考一下：
A was dissolved in DCM (250mL) and TFA (250mL) and stirred for 1h at ambient temperature. The mixture was evaporated to dryness and the residue dissolved in DCM (300mL), washed with 10% aqueous K2CO3 (2 × 200mL), and dried (MgSO4). Filtration and evaporation of the solvent and crystallisation of the residue from 2-propanol afforded B
谢谢！！！！！！！
这个不错！只是不知道异丙醇重结晶是不是适用于各种不同的脱Boc产物�
，
一般用水洗，水溶则重结晶比较好