看来有点难，换一个容易点的。从2-甲基萘出发合成6-甲氧基-2-甲基萘，除了磺化外还有其他路线吗？

给个英文名或是结构式,中文命名太弱......

[ Last edited by sibaken on 2007-1-31 at 16:04 ]

也许我说的名字不大对，现在给出结构式（见附件），请大家多帮忙。

[ Last edited by liuzy73 on 2007-2-1 at 08:54 ]

How about
2-methyl-6-nitro-naphthalene ---> 2-methyl-6-amino-naphthalene ---> 2-methyl-6-hydroxy-naphthalene  ---> 2-methyl-6-methoxy-naphthalene ???

[ Last edited by sibaken on 2007-2-1 at 09:04 ]

谢谢sibaken的回复。还得问一下，采用此路线时，硝化的选择性、还原剂和还原条件、胺在什么条件下交换成-OH以及最终的收率是否有资料可考？

   请斑竹转移10个金币给sibaken，祝贺你可以升级成银虫了！

[ Last edited by liuzy73 on 2007-2-1 at 14:11 ]

先别急着发金币,这是随手画的,不知是否可行,你得查一查.
还有另外一个想法,

2-methyl-naphthalene ---> 1-(6-methyl-[2]naphthyl)-ethanone ---> 6-methyl-[2]naphthyl acetate  ---> 2-methyl-6-hydroxy-naphthalen

Alcorn, P.G.E.; Wells, P.R., Aust. J. Chem., Volume 16, 1963, Pages 1108-1118
Weller; Kon, J. Chem. Soc., 1939, Pages 792
Brand; Dziewonski, Rocz. Chem., Volume 12, 1932, Pages 693, 695, 697
Pacheco, Henri;  Venco, C.;  Yavordios, D.; Saint-Martino Descours, Marie-Ange, Eur. J. Med. Chem. Chim. Ther., Volume 19, Issue 1, 1984, Pages 5-10，

for your reference
其他的请看信箱