法国FERREIRA Guillaume 教授拟招CSC博士生（神经生物学方向）
感兴趣的小伙伴抓紧时间联系，我有师兄在这个机构读博，对FERREIRA Guillaume 教授评价很高，教授人很好，课题组氛围融洽，研究课题十分严谨，如果不是和我专业不太符合，我怎会拱手相让，嘿嘿~~
Department/Institute: Unité Nutrition et Neurobiologie Intégrée
Supervising Scientist: Prof. FERREIRA Guillaume (Directeur de Recherche INRA)
Research Field: Neurobiology
Position: CSC-PhD Student
Project: Role of hippocampal CB1 receptors in obesity-induced memory impairments
Short Description:
In addition to serving as a major risk for cardiovascular and metabolic diseases, obesity is associated with cognitive impairments that pose a substantial threat to quality of life. Our team has been a pioneer in describing memory changes triggered by obesogenic diet consumption in rodent models (Boitard et al., 2012, 2014, 2015, 2016; Tantot et al., 2017; Naneix et al. 2017). In particular, using a combination of genetic and viral approaches, we recently identified that over-activation of the main cannabinoid receptors (CB1R) in hippocampus is a major contributor to obesity-induced memory impairments (Janthakin et al., in preparation). However, we indistinctly manipulated all the CB1R in hippocampus. As CB1R are expressed on different cell types (neurons and astrocytes) and on different cell compartments (plasma and mitochondrial membranes), it remains to identify which CB1R are involved in these effects.
Both neuronal and astroglial CB1R in hippocampus participates in the effects of cannabinoids on memory (Puighermanal et al., Nature Neuroscience, 2009; Han et al., Cell, 2012) and it was recently demonstrated that mitochondrial CB1R in hippocampus mediates memory impairment induced by cannabinoids (Hebert-Chatelain et al., Nature, 2016). Therefore, the main objective of this PhD project will be to identify which cell types (neuronal or astroglial) and which cell compartment (plasma or mitochondrial membranes) in the hippocampus are involved in CB1R-dependent memory impairment in obese mice.
This will improve our understanding of the role played by endocannabinoid system in memory alteration associated with obesity. It will also demonstrate whether manipulation of this system could represent an interesting strategy to alleviate cognitive impairments associated with obesity in order to improve well-being and the quality of life of this growing population.
Requirements:
Please see the attachments.

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