这个各个学科不是很一样，但是通用的格式是首先感谢审稿人提的建议和意见，然后说你们怎么修改的，要逐条回复审稿人的意见。大修以后能不能中主要是看审稿人对你们回复的评价，特别是他提的问题，一般是有机会的！good luck！下面是我以前写的！

Thank you for handling our manuscript "Title" with the
Manuscript Code: #####.

We highly cherish the referee's critiques and suggestions which help
us to improve our work. We have added some discussions in our
revised version according to the referee's comments. Below let me
summarize all the changes made in the new version.

Question 1
Answer 1

Question 2
Answer 2


We sincerely thank referee for his/her suggestions and comments. We
wish the changes and clarifications mentioned above, can answer the
referee's concerns.

Yours Sincerely，

thanks very much!