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1.        Chen M.*, Sun H*, Boot M, Lin S, Chang SJ, Wang W, Lam TT, Lara-Tejero M, Rego EH, Gal¨¢n JE. Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science. 2020 Jul 24;369(6502):450-455.  (IF=47.728)
2.        Chen M.*, Zhao, Z.*, Meng, Q.*, Liang, P.*, Su, Z., Wu, Y., Huang, J. and Cui, J., 2019. TRIM14 Promotes Noncanonical NF©\¦ÊB Activation by Modulating p100/p52 Stability via Selective Autophagy. Advanced Science, p.1901261. (IF=16.806)
3.        Chen M.*, Meng, Q.*, Qin, Y.*, Liang, P., Tan, P., He, L., Zhou, Y., Chen, Y., Huang, J., Wang, R.F. and Cui, J., 2016. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Molecular cell, 64(1), pp.105-119. (IF=15.584)
4.        Liu, T., Zhou, Y., Wang, L., Li, L., Bao, Q., Tian, S., Chen, M., Chen, H., Cui, J. and Li, C.W., 2019. NOD-like receptor family, pyrin domain containing 3 (NLRP3) contributes to inflammation, pyroptosis, and mucin production in human airway epithelium on rhinovirus infection. Journal of Allergy and Clinical Immunology, 144(3), pp.777-787. (IF=14.1)


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