我是用5-氨基喹啉和苯甲酰氯合成酰胺，下面是合成方法，但是每次都不成功，酰氯也是买的新的，大家知道为什么吗？求助



Add benzoyl chloride (1.05 equiv) dropwise to a stirred solution of 8-aminoquinoline (1 equiv) and Et3N (1.05 equiv) in anhydrous DCM (0.3 M) under argon at 0 °C.
Stir the resulting solution overnight at room temperature.
Dilute the reaction mixture with DCM.
Wash twice with water, twice with saturated aqueous NaHCO3 and then with brine.
Dry the organic layer over anhydrous Na2SO4 and concentrate under reduced pressure.
Purify the residue by column chromatography on silica gel, eluted with Cyclohexane/EtOAc (from [95:5] to [80:20]). 返回小木虫查看更多