荷兰maastricht university与csc的项目，荷兰方面maastricht university免学费，csc方面提供生活费，截止日期是4/15日。项目开始日期可商议，可能在10-12月，也可在线上择时开始展开。

dr. marian breuer学识渊博，拥有在美国illinois urbana-champaign, 英国university college london等名校学习和科研经验，为人非常有耐心，相信他会手把手带学生。荷兰的教学质量很高，生活宜居。荷兰人的英文水平普遍较好，可用英语直接交流。
马斯特里赫特大学（英文：maastricht university），是一所年轻但是享誉世界的名校。大学组建于1974年9月16日，前身为国立林堡大学，也是荷兰13所国立研究型大学之一，为世界大学联盟成员。
中心网站 www.maastrichtuniversity.nl/rese ... tre-systems-biology

对生源的要求：需要有较好的英语沟通能力（硬性的语言成绩不一定要有）。具有生化/计算机两者至少其一的相关背景。
感兴趣者请将英文版cv和transcript发送至 dr. marian breuer, marian.breuer@maastrichtuniversity.nl， 并咨询其他信息。

project title: targeting cellular ageing and senescence through metabolic modelling
project leader: dr. marian breuer
function: assistant professor
collaborators: dr. michiel adriaens, prof. dr. ilja arts

introduction: the ageing of populations creates a major public health burden around the world. ageing involves intertwined processes on cellular and tissue levels. in particular, cellular senescence, a heterogeneous phenotype of permanent growth arrest, is an important driver of ageing in tissues. interventions against ageing, e.g. by targeting this senescent state, could extend the healthy lifespan and contribute to regenerative medicine. cellular senescence has significant ties to metabolism, suggesting potential intervention strategies; however, these ties are insufficiently characterized.

hypothesis and objectives: this project will study the metabolic changes accompanying cellular ageing and in particular senescence with the goal of identifying possible new signatures and biomarkers, as well as possible metabolic targets for more selective and specific drugs against senescent cells.
setting and methods: metabolic networks of young, aged and senescent human cells will be reconstructed using omics data like transcriptomics and epigenomics. in silico metabolic modeling will be used to analyze and compare metabolic features between conditions. this comparison will not only shed light on the metabolic signatures of cellular ageing and senescence, but also identify intervention targets that could revert the ageing process at cellular level.

impact: the discovery of specific metabolic intervention targets will aid the development of more specific anti-senescence drugs. the development of metabolic signatures and biomarkers could aid in the identification and monitoring of senescent cells, which would be necessary to study the efficacy of anti-senescence drugs. overall, this project will aid the development of anti-ageing precision medicine ╟ ultimately promoting healthy ageing in the population.

requirements candidate: highly motivated student with good english communication skills and proactive and resolute attitude. the ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in matlab. applications with background in only the biochemical or computational side are still possible, but the applicant would need to make a convincing impression of being able to catch up in the other aspect.

keywords: biological foundations of human health and diseases, major new drugs discovery, systems biology, metabolic modelling, ageing

top 5 selected publications:
1. m. breuer, t. m. earnest, c. merryman, k. s. wise, l. sun, m. r. lynott, c. a. hutchison iii, h. o. smith, j. d. lapek jr., d. j. gonzalez, v. de crécy-lagard, d. haas, a. d. hanson, p. labhsetwar, j. i. glass, z. luthey-schulten “essential metabolism for a minimal cell” elife (2019), 8:e36842. citations (web of science): 9
2. prickaerts, p.*, adriaens, m.e.*, beucken, t.. et al. “hypoxia increases genome-wide bivalent epigenetic marking by specific gain of h3k27me3”, epigenetics & chromatin (2016), 9: 46. citations (web of science): 21
3. m. breuer, k. m. rosso, j. blumberger “electron flow in multi-heme bacterial cytochromes is a balancing act between heme electronic interaction and redox potentials”, proc. natl. acad. sci. usa (2014), 111: 611. citations (web of science): 96
4. x. jiang, b. burger, f. gajdos, c. bortolotti, z. futera, m. breuer, j. blumberger “kinetics of trifurcated electron flow in the decaheme bacterial proteins mtrc and mtrf“ proc. natl. acad. sci. usa (2019) 116: 3425. citations (web of science): 5
5. m. breuer, k. m. rosso, j. blumberger, j. n. butt “multi-haem cytochromes in shewanella oneidensis mr-1: structures, functions and opportunities”, j. r. soc. interface (2015) 12: 20141117. citations (web of science): 86

[ last edited by strawberrix on 2020-4-10 at 09:23 ]

p.s. applicants should ideally receive master's degree this year, and at most should have received their master's degree last year.

[ last edited by strawberrix on 2020-4-12 at 21:48 ]

Deadline extended to 24th April, but the opening will be closed once a suitable candidate is found.

[ Last edited by Strawberrix on 2020-4-20 at 20:15 ] 返回小木虫查看更多