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Strawberrix

新虫 (小有名气)

[交流] metabolic modelling (荷兰马斯特里赫特大学),无需语言成绩,截止日期4/15

荷兰maastricht university与csc的项目,荷兰方面maastricht university免学费,csc方面提供生活费,截止日期是4/15日。项目开始日期可商议,可能在10-12月,也可在线上择时开始展开。

dr. marian breuer学识渊博,拥有在美国illinois urbana-champaign, 英国university college london等名校学习和科研经验,为人非常有耐心,相信他会手把手带学生。荷兰的教学质量很高,生活宜居。荷兰人的英文水平普遍较好,可用英语直接交流。
马斯特里赫特大学(英文:maastricht university),是一所年轻但是享誉世界的名校。大学组建于1974年9月16日,前身为国立林堡大学,也是荷兰13所国立研究型大学之一,为世界大学联盟成员。
中心网站 www.maastrichtuniversity.nl/rese ... tre-systems-biology

对生源的要求:需要有较好的英语沟通能力(硬性的语言成绩不一定要有)。具有生化/计算机两者至少其一的相关背景。
感兴趣者请将英文版cv和transcript发送至 dr. marian breuer, marian.breuer@maastrichtuniversity.nl, 并咨询其他信息。

project title: targeting cellular ageing and senescence through metabolic modelling
project leader: dr. marian breuer
function: assistant professor
collaborators: dr. michiel adriaens, prof. dr. ilja arts

introduction: the ageing of populations creates a major public health burden around the world. ageing involves intertwined processes on cellular and tissue levels. in particular, cellular senescence, a heterogeneous phenotype of permanent growth arrest, is an important driver of ageing in tissues. interventions against ageing, e.g. by targeting this senescent state, could extend the healthy lifespan and contribute to regenerative medicine. cellular senescence has significant ties to metabolism, suggesting potential intervention strategies; however, these ties are insufficiently characterized.

hypothesis and objectives: this project will study the metabolic changes accompanying cellular ageing and in particular senescence with the goal of identifying possible new signatures and biomarkers, as well as possible metabolic targets for more selective and specific drugs against senescent cells.
setting and methods: metabolic networks of young, aged and senescent human cells will be reconstructed using omics data like transcriptomics and epigenomics. in silico metabolic modeling will be used to analyze and compare metabolic features between conditions. this comparison will not only shed light on the metabolic signatures of cellular ageing and senescence, but also identify intervention targets that could revert the ageing process at cellular level.

impact: the discovery of specific metabolic intervention targets will aid the development of more specific anti-senescence drugs. the development of metabolic signatures and biomarkers could aid in the identification and monitoring of senescent cells, which would be necessary to study the efficacy of anti-senescence drugs. overall, this project will aid the development of anti-ageing precision medicine ╟ ultimately promoting healthy ageing in the population.

requirements candidate: highly motivated student with good english communication skills and proactive and resolute attitude. the ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in matlab. applications with background in only the biochemical or computational side are still possible, but the applicant would need to make a convincing impression of being able to catch up in the other aspect.

keywords: biological foundations of human health and diseases, major new drugs discovery, systems biology, metabolic modelling, ageing

top 5 selected publications:
1. m. breuer, t. m. earnest, c. merryman, k. s. wise, l. sun, m. r. lynott, c. a. hutchison iii, h. o. smith, j. d. lapek jr., d. j. gonzalez, v. de crécy-lagard, d. haas, a. d. hanson, p. labhsetwar, j. i. glass, z. luthey-schulten “essential metabolism for a minimal cell” elife (2019), 8:e36842. citations (web of science): 9
2. prickaerts, p.*, adriaens, m.e.*, beucken, t.. et al. “hypoxia increases genome-wide bivalent epigenetic marking by specific gain of h3k27me3”, epigenetics & chromatin (2016), 9: 46. citations (web of science): 21
3. m. breuer, k. m. rosso, j. blumberger “electron flow in multi-heme bacterial cytochromes is a balancing act between heme electronic interaction and redox potentials”, proc. natl. acad. sci. usa (2014), 111: 611. citations (web of science): 96
4. x. jiang, b. burger, f. gajdos, c. bortolotti, z. futera, m. breuer, j. blumberger “kinetics of trifurcated electron flow in the decaheme bacterial proteins mtrc and mtrf“ proc. natl. acad. sci. usa (2019) 116: 3425. citations (web of science): 5
5. m. breuer, k. m. rosso, j. blumberger, j. n. butt “multi-haem cytochromes in shewanella oneidensis mr-1: structures, functions and opportunities”, j. r. soc. interface (2015) 12: 20141117. citations (web of science): 86

[ last edited by strawberrix on 2020-4-10 at 09:23 ]

p.s. applicants should ideally receive master's degree this year, and at most should have received their master's degree last year.

[ last edited by strawberrix on 2020-4-12 at 21:48 ]

Deadline extended to 24th April, but the opening will be closed once a suitable candidate is found.

[ Last edited by Strawberrix on 2020-4-20 at 20:15 ]
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dongdong8881

铁杆木虫 (著名写手)

引用回帖:
13楼: Originally posted by Strawberrix at 2020-04-08 20:30:10
欧洲博士3-4年。
技术方面不必太担心,学起来很快,该有的培训也自然会有,而且若有相关产生的费用应该有导师承担。具体是否系里自己开办还是要参加学校层面的培训要问老师。...

马大的项目为什么可以免试雅思等考试?

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14楼2020-04-08 22:45:25
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Strawberrix

新虫 (小有名气)

引用回帖:
4楼: Originally posted by dongdong8881 at 2020-04-08 13:28:56
有没有该项目的细则说明?CSC资助程度如何?

你好,四月在department内部讨论,4/30统一提交CSC那边. 如对项目感兴趣,不妨直接将CV发给老师,并咨询更多的细则。 关于CSC资助的生活费力度,一般来说按月发放,能够满足日常生活,每年回国一次,欧洲再游玩一次,是没问题的; 要想存得下钱那是不现实的。
5楼2020-04-08 13:54:00
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Strawberrix

新虫 (小有名气)

引用回帖:
8楼: Originally posted by 亲空 at 2020-04-08 14:46:52
马斯特里赫特的有保证的csc名额不是都已经出来名单了吗?怎么还能再招生啊?

不清楚,对研究方向感兴趣的话请直接联系该导师询问
9楼2020-04-08 15:02:17
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Adam Cole

新虫 (正式写手)

10楼2020-04-08 15:39:32
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Strawberrix

新虫 (小有名气)

引用回帖:
11楼: Originally posted by dongdong8881 at 2020-04-08 16:23:09
如果涉及建模,生物化学背景的学生实验室是否支持学习一些计算机语言完成建模?以及博士的学制是几年?
...

欧洲博士3-4年。
技术方面不必太担心,学起来很快,该有的培训也自然会有,而且若有相关产生的费用应该有导师承担。具体是否系里自己开办还是要参加学校层面的培训要问老师。
13楼2020-04-08 20:30:10
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Strawberrix

新虫 (小有名气)

引用回帖:
14楼: Originally posted by dongdong8881 at 2020-04-08 22:45:25
马大的项目为什么可以免试雅思等考试?
...

引用老师的原话了
“No English test is required; if a candidate has no IELTS or other score, I as supervisor would just have to add a statement to their CSC application that I deem their English skills adequate. ”
当然有语言成绩会更好
15楼2020-04-09 15:35:03
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Strawberrix

新虫 (小有名气)

引用回帖:
16楼: Originally posted by dongdong8881 at 2020-04-10 08:26:50
163网易邮箱发给Dr.Marian Breuer了,没有回复,是没收到?

不好意思,他说收到了很多申请,暂时没看到专业背景特别符合的。他于是增加了门槛,需要至少懂生化/计算机两者其一的,要把CV和成绩单都发过去。要是自己符合新提出的条件,之前的邮件没有凸出这方面达标,可以重发邮件。
17楼2020-04-10 09:28:07
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普通回帖

jzyhh12345

新虫 (小有名气)

2楼2020-04-08 11:16:57
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考研党预备

禁虫 (小有名气)

本帖内容被屏蔽
3楼2020-04-08 11:35:14
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dongdong8881

铁杆木虫 (著名写手)

有没有该项目的细则说明?CSC资助程度如何?

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4楼2020-04-08 13:28:56
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Strawberrix

新虫 (小有名气)

引用回帖:
3楼: Originally posted by 考研党预备 at 2020-04-08 11:35:14
机械电子工程专业要吗

你好,感谢你的兴趣!专业不是最主要的,当然如果之前的专业要是有transferrable skill (eg,programming,maths,physics,chemistry)那会比较有优势。如对项目感兴趣,能够接受转生物,不妨直接将CV发给老师询问。这个研究领域属于system biology的metabolic modelling。
6楼2020-04-08 13:58:16
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Strawberrix

新虫 (小有名气)

引用回帖:
2楼: Originally posted by jzyhh12345 at 2020-04-08 11:16:57
材料专业要吗

见上楼回复
7楼2020-04-08 14:01:42
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亲空

铜虫 (小有名气)

马斯特里赫特的有保证的csc名额不是都已经出来名单了吗?怎么还能再招生啊?
8楼2020-04-08 14:46:52
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