投的是medical science monitor,是一篇生信的文章，也是我第一篇sci，目前的状态是“Sent to author(s) for corrections (3 weeks) ”。
返回的三个意见感觉都满尖锐的
一：分析的mRNA的变化不能反应蛋白的变化，毕竟蛋白的变化更重要。为何选择该mRNA进行分析，毕竟一个mRNA的变化不能反应疾病的全貌。。。
这个我大概还是能解释的
二：
Title and abstract
Spaces either missing or are too many throughout the manuscript.
Introduction
The introduction should include more  background.
Material and Methods
Details of the search should be included in the method section. There should not be only one keyword. The ethics aspects need to be disclosed and appropriate ethics committee approval must be quoted. Besides mRNA populations, microRNAs (miRNAs) may be equally important in AD. Gloabaly, I would suggest authors to add a interaction of mRNA expression with miRNA. Becauxe single-level research does not fully explain the mechanism of disease development.
References
This is not believable, and the references are too old and not representative. Does this manuscript reference previous literature appropriately?

General comments to the Authors
The manuscript is poorly written and is full of strange words and expressions and should be proof-read by an English-speaking person.
三：
Introduction
The introduction is not in a correct format. In this part the authors should discuss more ( around a page) about previous findings and the link between their study and these previous findings. They should on the other hand shorten the length of their explanation about what they re going to do to two or three general lines of explanation.

Discussion
Discussion is short. The authors should discuss more on the association of mRNA and AD and the downstream pathways that relate these two to each other. How these changes in mRNA levels can justify the histopathological changes in AD should be discussed more.

What are the limitations of this study?

Conclusions
Just a line of conclusion has been presented. Please explain your conclusions clearly. Future directions and clinical implications of these conclusions should be presented too.

General comments to the Authors
The manuscript need extensive and thorough language proofreading by an expert.

让我三个星期内改，说实话还是比较打击自信的。因为第一次投稿，也不知道这些审稿意见的尖锐程度正常么，意思就是我的文章英文水平很low（雅思7分），然后很多地方都有问题。。三周之内改。大家觉得这篇文章还有戏么，是不是应该找个什么机构润色一下。 返回小木虫查看更多