路篓鹿煤虏篓露没露脿麓贸脩搂institute european chemistry and biology 拢篓IECB) Guichard 驴脦脤芒脳茅鲁脧脮脨鹿芦脜脡虏漏脢驴

驴脦脤芒拢潞Design and synthesis of foldamer-based enzyme mimetics

录貌陆茅拢潞

            In Nature, folding and function of biopolymers, such as proteins or nucleic acids, are two closely related notions that lead to an impressive variety of biological processes to occur. The design of bioinspired architectures to create innovative and functional nano(bio)systems in aqueous
media has been a longstanding goal of the scientific community. Access to artificial enzymatic systems that would lead to efficient and new biocatalysts is of particular interest. Synthetic sequence-specific folded oligomers (also called 隆掳foldamers隆卤) possess interesting features to create self-assembled protein-like frameworks, with topologies similar to and beyond those of natural polypeptides. The ability of some foldamer backbones to form predictable and well-defined secondary structures, with helical folding properties being independent from the nature of the side-chain used (i.e. primary sequence), should facilitate morphological control at the nano-scale while displaying the desired functionalities. However, attempts to reproduce enzymatic activities using foldamer chemistry have remained limited thus far.

Our group has pioneered the development and the structural characterization of aliphatic oligoureas as a new class of peptidomimetic foldamers during the last decade. The remarkable compatibility of their backbones with alpha-peptides has been recently demonstrated, highlighting thus the potential of interfacing natural peptides and ureabased backbones to create chimeric structures. Thus this PhD project aims
to engineer de novo enzyme-like architectures using supramolecular assemblies of water-soluble peptide-oligourea chimera.

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脢碌脩茅脢脪陆茅脡脺拢潞 CBMN-UMR 5248 Guichard 驴脦脤芒脳茅脫脡虏篓露没露脿麓贸脩搂潞脥路篓鹿煤驴脝脩搂脭潞拢篓CNRS拢漏脕陋潞脧脳茅鲁脡拢卢掳眉脌篓虏篓露没露脿麓贸脩搂脰掳鹿陇潞脥路篓鹿煤驴脝脩搂脭潞脩脨戮驴脭卤鹿虏脥卢脩脨戮驴隆拢 脳茅脛脷脫脨脌麓脳脭脜路脰脼潞脥脩脟脰脼露脿赂枚鹿煤录脪碌脛虏漏脢驴脡煤潞脥虏漏脢驴潞贸拢卢驴脝脩脨路脮脦搂潞脙拢卢脢碌脩茅脡猫卤赂脝毛脠芦拢卢脌脧掳氓脠脣脪虏nice隆拢 脧锚脟茅脟毛驴麓脢碌脩茅脢脪脰梅脪鲁拢潞 https://www.cbmn.u-bordeaux.fr/1 ... que.html#teamleader

赂脨脨脣脠陇碌脛脥卢脩搂脟毛路垄脣脥 CV潞脥cover letter 赂酶 Morgane Pasco (m.pasco@iecb.u-bordeaux.fr, +33 5 4000 3015)

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