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Relative tissue distribution and excretion studies of gastrodin and parishin from powder and extract of Gastrodiae Rhizoma in rat by UHPLC-ESI-MS/MS.


作者:Jiang, Zhengmeng; Zheng, Xiuyan; Gong, Xiaojian; Zhao, Chao; Zhou, Xin; Zhao, Yang; Yan, Yanfang




Biomedical chromatography : BMC


DOI:10.1002/bmc.3909

出版年:2016-Dec-07 (Epub 2016 Dec 07)


摘要



New research has indicated that Gastrodiae Rhizome (GR) has potential anti-diabetic and anti-asthmatic effects in mouse models. On the basis of our previous study of the relative bioavailability of gastrodin (GAS) and parishin (PA) from extract and powder of GR, we performed further research on the tissue distribution and excretion of the two analytes. A reliable bioanalytical method for the quantification of GAS and PA in rat tissues and excretion is required. Chromatographic separation was carried out on a gradient mobile phase of acetonitrile-water with 0.1% formic acid. Calibration curves (1/x2 weighted) offered satisfactory linearity (r2 >0.9835) within 100-3000ngmL-1 for GAS and (r2 >0.9862) within 10-1000ngmL-1 for PA. The relative standard deviations of the intra-day and inter-day precision were all <14.98%, whilst the relative errors of the intra-day and inter-day accuracy were all within ±14.71%. The matrix effect and recovery values were satisfactory in all of the biological matrices examination. The data of relative differences in tissue distribution and excretion of GAS and PA from powder and extract of GR indicated that higher bioavailabilities for GAS and PA were obtained when a dosage of 4gkg-1 GR powder was used.
Copyright 2016 John Wiley & Sons, Ltd.


关键词

关键词列表:Gastrodiae Rhizome; UHPLC-ESI-MS/MS; bioavailability; gastrodin and parishin; tissue distribution and excretion studies


作者信息

地址:Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang, Guizhou, People's Republic of China.


文献信息

文献类型:Journal Article

语种:English

PubMed ID:27925254

NLM 唯一 ID:8610241

创建日期:  07 Dec 2016          修订日期:  24 Jan 2017

电子出版:07 Dec 2016

国家/地区: England

ISSN:1099-0801

好像不是SCI，

不是ＳＣＩ收录，但是属于PubMed

可能还没有检索到，该期刊应该是ＳＣＩ，可能还要１－２个月才可以检索到

BIOMEDICAL CHROMATOGRAPHY
Monthly ISSN: 0269-3879
WILEY, 111 RIVER ST, HOBOKEN, USA, NJ, 07030-5774
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Science Citation Index
Science Citation Index Expanded
Current Contents - Life Sciences
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SCI检索的期刊上发表的文章会被SCI检索，不过时间不同，有些期刊可能需要半年左右。