PhD Projects in Theoretical / Computational Biophysics

Project 1: In Silico Analysis and Design of Protein-DNA Interaction Surfaces

Problems:
• DNA-binding proteins trigger conformational changes in DNA
• Specificity of proteins for DNA sequences and structures are largely unknown
Aims:
• Analysis of protein-DNA interaction surfaces
• Prediction of mutational effects on protein-DNA binding
• Design of DNA-binding proteins with pre-defined specificities


Project 2: Effect of General Anesthetics on Biological Membranes Studied in Simulations

Problems:
• Molecular mechanisms underlying the effect of anesthetics largely unknown
Aims:
• Modeling of biological membrane mimics
• Force field development for different lipid types
• Study of the effect of different anesthetics in molecular dynamics simulations both on the membrane and on ion channels


Project 3: Pore Formation in Biological Membranes by Electric Fields and Anitibiotic Peptides

Problems:
• Characteristics of Membrane Pore Formation
Aims:
• Modeling of biological membrane mimics
• Force field development for different lipid types
• Effect of different antibiotic peptides and electric fields on biological membranes, peptide design

Requirements:

Bachelor/Master in Chemistry, Physics, or Bioinformatics, Linux experience

We offer:

international working environment, state-of-the-art computational resources, participation in international conferences

Further information:

Please contact             Prof. Rainer Böckmann
                                   E-mail: rainer.boeckmann@biologie.uni-erlangen.de
                                   Phone: 0049 - 9131/85-25409

__________________________________________________________
Prof. Dr. Rainer Böckmann
Computational Biology
Universität Erlangen-N¨¹rnberg
Staudtstr. 5
91058 Erlangen
Phone:        ++49 +9131 85-25409                  FAX: ++49 +9131 85-25410
E-Mail: rainer.boeckmann@biologie.uni-erlangen.de
http://www.biotechnik.nat.uni-erlangen.de/research/boeckmann/

[ Last edited by flyingskynk on 2012-5-18 at 23:25 ] ·µ»ØСľ³æ²é¿´¸ü¶à