直接用氯化亚砜作溶剂，回流几小时试试

仲位的的比较难做，催化剂可选用DMF  三乙胺，氯化剂选用SOCl2  PCl3  BTC等 ，可以不考虑PCL5.

找到一篇相似的文献  用吡啶做溶剂DMF做催化剂
具体操作  To a mixture of fluorinated alcohol (85.2 mmol) and
pyridine (93.7 mmol) was slowly added thionyl chloride
(93.7 mmol) and catalytic amount of DMF (0.1 mol%).
The mixture was refluxed for 3–5 h and poured into cold
water (20 mL). The organic layer was separated and the
aqueous layer extracted with dichloromethane (3  25 mL).
The combined organics extracts were washed with diluted
HCl (4  40 mL), water (2  40 mL), saturated sodium
bicarbonate (2  40 mL) and brine. Evaporation of the
solvent yielded the crude product which was purified by
distillation，

出处 Journal of Fluorine Chemistry 126 (2005) 1174–1184

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如果你的目的是下一步亲核取代，见意羟基TS化。
我作过1位是三氟甲基的醇为原料的亲核取代。（是一个N烷基化）
1位2位取代的醇是有明显反应差别的

[ Last edited by mcbauon on 2008-10-8 at 10:41 ]

建议：1）如果用二氯亚砜做氯化剂，可以用苯并三氮唑做碱，效果会好些；
         2）在这个反应中，二氯亚砜不是一个好的氯化剂，可以用三苯基磷的氯化试剂进行反应，可能会得到较好的结果；

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骗人你还有3700多金币呢 这么抠门