我在做合成 酰胺反应，想要 先和成酰氯。完全按照文献做的。如文献
Oxalyl chloride （草酰氯）(3.10 g, 24 mmol) was drop-wise added to a
stirred solution of 4-(N,N-dimethylamino)benzoic acid (1.00 g, 6
mmol) in dry dichloromethane (20 mL) with 3 drops of dry pyridine.
After further stirring for 30 minutes the solvent was
removed under reduced pressure to yield an off-white powder,
1.06 g (96%), mp135 – 136º (lit. 135 – 136&ordm
原料酸是不容与二氯甲烷的。可是这个反应好像根本为进行。反应了1小时后。反应液里还有好多固体。点板也看不出来。脱了好长的一条线。
有知道是怎么 回事的 吗 ？
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