24小时热门版块排行榜    

Znn3bq.jpeg
查看: 1808  |  回复: 7
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

dinghuachen

铁杆木虫 (正式写手)


[交流] 关于血浆蛋白!

一般纳米材料进入人体后,表面往往会吸附一层血浆蛋白,然后有可能导致被巨噬细胞吞噬。我想问的是,纳米材料被巨噬细胞所吞噬肯定是由于血浆蛋白的吸附所引起的,不过为何单个或者几个血浆蛋白的聚合体在人体内不会被巨噬细胞所吞噬呢?或者说,巨噬细胞是如何区分它吞进的是纳米蛋白复合体还是血浆蛋白呢(特别是纳米材料尺寸不是很大的情况下)?

[ Last edited by dinghuachen on 2013-10-3 at 20:55 ]
回复此楼

» 猜你喜欢

» 本主题相关商家推荐: (我也要在这里推广)

» 本主题相关价值贴推荐,对您同样有帮助:

» 抢金币啦!回帖就可以得到:

查看全部散金贴

已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

dinghuachen

铁杆木虫 (正式写手)


引用回帖:
3楼: Originally posted by 晚香玉 at 2013-10-04 00:25:08
不吸附血浆蛋白也会吞噬,胞吞作用很常见

恩,是的,不过纳米粒子在吸附蛋白之后被吞噬的更明显了。可是我比较疑惑的是,既然纳米载体在吸附蛋白后更容易被吞噬(蛋白上面肯定有特定靶点跟巨噬细胞表面受体作用),为何血浆蛋白自身不会吸附到巨噬细胞表面然后被内吞呢?
5楼2013-10-04 15:50:52
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 8 个回答
★ ★
小木虫: 金币+0.5, 给个红包,谢谢回帖
红舟流星: 金币+1, 专家考核, 欢迎来生物材料板块应助交流 2013-10-03 23:36:30
Here is an excellent paper from the Discher lab to address your question:
Science. 2013 Feb 22;339(6122):971-5. doi: 10.1126/science.1229568, Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
Abstract
''Foreign particles and cells are cleared from the body by phagocytes that must also recognize and avoid clearance of "self" cells. The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a. Minimal "Self" peptides were computationally designed from human CD47 and then synthesized and attached to virus-size particles for intravenous injection into mice that express a CD172a variant compatible with hCD47. Self peptides delay macrophage-mediated clearance of nanoparticles, which promotes persistent circulation that enhances dye and drug delivery to tumors. Self-peptide affinity for CD172a is near the optimum measured for human CD172a variants, and Self peptide also potently inhibits nanoparticle uptake mediated by the contractile cytoskeleton. The reductionist approach reveals the importance of human Self peptides and their utility in enhancing drug delivery and imaging.''
2楼2013-10-03 22:33:37
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

晚香玉

木虫 (正式写手)



小木虫: 金币+0.5, 给个红包,谢谢回帖
不吸附血浆蛋白也会吞噬,胞吞作用很常见

[ 发自手机版 http://muchong.com/3g ]
3楼2013-10-04 00:25:08
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

jinwei331

至尊木虫 (文坛精英)


……………………
4楼2013-10-04 06:35:50
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
普通表情 高级回复 (可上传附件)
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[考研] 化工调剂求导师收留!一志愿失利,踏实肯干,有植物提取科研经历 +7 yzyzx 2026-04-09 7/350 2026-04-09 23:21 by may_新宇
[考研] 求调剂 +5 archer.. 2026-04-09 7/350 2026-04-09 22:18 by lbsjt
[考研] 297求调剂 +22 ljy20040718! 2026-04-03 24/1200 2026-04-09 20:48 by yanenwang
[考研] 一志愿0703化学招61最终排名62化学求调剂 +16 招61排名62 2026-04-07 19/950 2026-04-09 20:44 by zhouxiaoyu
[考研] 284求调剂 +8 让我上岸吧阿西 2026-04-09 10/500 2026-04-09 18:34 by 段伟艳
[考研] 本科郑州大学,一志愿华东师范大学282求调剂 +23 熊哥xtk 2026-04-07 26/1300 2026-04-09 17:17 by 18446523
[考研] 材料工程085601,270求调剂 +26 @ASDF1234 2026-04-08 28/1400 2026-04-09 15:47 by wp06
[基金申请] 有爆料,一个青年教师卖房得400万,然后换了一个四青帽子 +6 babu2015 2026-04-08 6/300 2026-04-09 08:14 by kudofaye
[考研] 专硕0854初试考材科基,求调剂 +7 3220548044 2026-04-06 10/500 2026-04-08 21:59 by hypershenger
[考研] 化学0703-一志愿211-338分求调剂 +10 vants 2026-04-05 11/550 2026-04-08 16:02 by screening
[考研] 22408 266求调剂 +11 masss11222 2026-04-07 14/700 2026-04-08 11:06 by yulian1987
[考研] 313求调剂 +3 十六拾陆 2026-04-07 3/150 2026-04-07 23:20 by lbsjt
[论文投稿] Decision: Revise for Editor还会送审吗 100+3 CccccccccFD 2026-04-04 5/250 2026-04-07 10:58 by 北京莱茵润色
[考研] 软工学硕299求调剂 +6 useryy 2026-04-07 6/300 2026-04-07 09:50 by vgtyfty
[考研] 华南理工0703化学,总分336求调剂 +10 手机用户 2026-04-03 11/550 2026-04-06 22:20 by michael2011
[考研] 0857大类环境工程B区求调剂 +3 龚禹铭 2026-04-05 3/150 2026-04-06 10:22 by 蓝云思雨
[考研] 331求调剂 +8 于征yz 2026-04-05 8/400 2026-04-06 00:54 by fmesaito
[考研] 材料专硕(0856) 339分求调剂 +10 哈哈哈鹅哈哈哈 2026-04-04 10/500 2026-04-05 18:51 by 蓝云思雨
[考研] 085600调剂 +9 东照照照 2026-04-04 9/450 2026-04-05 13:44 by ujn_zhuj
[考研] 309求调剂 +4 快乐的小白鸽 2026-04-04 5/250 2026-04-04 15:55 by cql1109
信息提示
请填处理意见