Znn3bq.jpeg
²é¿´: 1804  |  »Ø¸´: 7

dinghuachen

Ìú¸Ëľ³æ (ÕýʽдÊÖ)


[½»Á÷] ¹ØÓÚѪ½¬µ°°×£¡

Ò»°ãÄÉÃײÄÁϽøÈëÈËÌåºó£¬±íÃæÍùÍù»áÎü¸½Ò»²ãѪ½¬µ°°×£¬È»ºóÓпÉÄܵ¼Ö±»¾ÞÊÉϸ°ûÍÌÊÉ¡£ÎÒÏëÎʵÄÊÇ£¬ÄÉÃײÄÁϱ»¾ÞÊÉϸ°ûËùÍÌÊɿ϶¨ÊÇÓÉÓÚѪ½¬µ°°×µÄÎü¸½ËùÒýÆðµÄ£¬²»¹ýΪºÎµ¥¸ö»òÕß¼¸¸öѪ½¬µ°°×µÄ¾ÛºÏÌåÔÚÈËÌåÄÚ²»»á±»¾ÞÊÉϸ°ûËùÍÌÊÉÄØ£¿»òÕß˵£¬¾ÞÊÉϸ°ûÊÇÈçºÎÇø·ÖËüÍ̽øµÄÊÇÄÉÃ×µ°°×¸´ºÏÌ廹ÊÇѪ½¬µ°°×ÄØ£¨ÌرðÊÇÄÉÃײÄÁϳߴ粻ÊǺܴóµÄÇé¿öÏ£©£¿

[ Last edited by dinghuachen on 2013-10-3 at 20:55 ]
»Ø¸´´ËÂ¥

» ²ÂÄãϲ»¶

» ±¾Ö÷ÌâÏà¹ØÉ̼ÒÍÆ¼ö: (ÎÒÒ²ÒªÔÚÕâÀïÍÆ¹ã)

» ±¾Ö÷ÌâÏà¹Ø¼ÛÖµÌùÍÆ¼ö£¬¶ÔÄúͬÑùÓаïÖú:

» ÇÀ½ð±ÒÀ²£¡»ØÌû¾Í¿ÉÒԵõ½:

²é¿´È«²¿É¢½ðÌù

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
¡ï ¡ï
Сľ³æ: ½ð±Ò+0.5, ¸ø¸öºì°ü£¬Ð»Ð»»ØÌû
ºìÖÛÁ÷ÐÇ: ½ð±Ò+1, ר¼Ò¿¼ºË, »¶Ó­À´ÉúÎï²ÄÁϰå¿éÓ¦Öú½»Á÷ 2013-10-03 23:36:30
Here is an excellent paper from the Discher lab to address your question:
Science. 2013 Feb 22;339(6122):971-5. doi: 10.1126/science.1229568, Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
Abstract
''Foreign particles and cells are cleared from the body by phagocytes that must also recognize and avoid clearance of "self" cells. The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a. Minimal "Self" peptides were computationally designed from human CD47 and then synthesized and attached to virus-size particles for intravenous injection into mice that express a CD172a variant compatible with hCD47. Self peptides delay macrophage-mediated clearance of nanoparticles, which promotes persistent circulation that enhances dye and drug delivery to tumors. Self-peptide affinity for CD172a is near the optimum measured for human CD172a variants, and Self peptide also potently inhibits nanoparticle uptake mediated by the contractile cytoskeleton. The reductionist approach reveals the importance of human Self peptides and their utility in enhancing drug delivery and imaging.''
2Â¥2013-10-03 22:33:37
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

ÍíÏãÓñ

ľ³æ (ÕýʽдÊÖ)


¡ï
Сľ³æ: ½ð±Ò+0.5, ¸ø¸öºì°ü£¬Ð»Ð»»ØÌû
²»Îü¸½Ñª½¬µ°°×Ò²»áÍÌÊÉ£¬°ûÍÌ×÷Óúܳ£¼û

[ ·¢×ÔÊÖ»ú°æ http://muchong.com/3g ]
3Â¥2013-10-04 00:25:08
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

jinwei331

ÖÁ×ðľ³æ (ÎÄ̳¾«Ó¢)


¡­¡­¡­¡­¡­¡­¡­¡­
4Â¥2013-10-04 06:35:50
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

dinghuachen

Ìú¸Ëľ³æ (ÕýʽдÊÖ)


ÒýÓûØÌû:
3Â¥: Originally posted by ÍíÏãÓñ at 2013-10-04 00:25:08
²»Îü¸½Ñª½¬µ°°×Ò²»áÍÌÊÉ£¬°ûÍÌ×÷Óúܳ£¼û

¶÷£¬Êǵ쬲»¹ýÄÉÃ×Á£×ÓÔÚÎü¸½µ°°×Ö®ºó±»ÍÌÊɵĸüÃ÷ÏÔÁË¡£¿ÉÊÇÎұȽÏÒÉ»óµÄÊÇ£¬¼ÈÈ»ÄÉÃ×ÔØÌåÔÚÎü¸½µ°°×ºó¸üÈÝÒ×±»ÍÌÊÉ£¨µ°°×ÉÏÃæ¿Ï¶¨ÓÐÌØ¶¨°Ðµã¸ú¾ÞÊÉϸ°û±íÃæÊÜÌå×÷Óã©£¬ÎªºÎѪ½¬µ°°××ÔÉí²»»áÎü¸½µ½¾ÞÊÉϸ°û±íÃæÈ»ºó±»ÄÚÍÌÄØ£¿
5Â¥2013-10-04 15:50:52
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

dinghuachen

Ìú¸Ëľ³æ (ÕýʽдÊÖ)


ÒýÓûØÌû:
2Â¥: Originally posted by aircraftvip at 2013-10-03 22:33:37
Here is an excellent paper from the Discher lab to address your question:
Science. 2013 Feb 22;339(6122):971-5. doi: 10.1126/science.1229568, Minimal "Self" peptides that inhibit phagocyt ...

·Ç³£¸ÐлÄãÌṩµÄÎÄÕ£¬²»¹ýÎÒ»¹ÊÇÓÐÈçÏÂÒɻ󣬼ÈÈ»ÄÉÃ×ÔØÌåÔÚÎü¸½µ°°×ºó¸üÈÝÒ×±»ÍÌÊÉ£¨µ°°×ÉÏÃæ¿Ï¶¨ÓÐÌØ¶¨°Ðµã¸ú¾ÞÊÉϸ°û±íÃæÊÜÌå×÷Óã©£¬ÎªºÎѪ½¬µ°°××ÔÉí²»»áÎü¸½µ½¾ÞÊÉϸ°û±íÃæÈ»ºó±»ÄÚÍÌÄØ£¿
6Â¥2013-10-04 15:51:53
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
Сľ³æ: ½ð±Ò+0.5, ¸ø¸öºì°ü£¬Ð»Ð»»ØÌû
dinghuachen: ½ð±Ò+5, лл»Ø´ð£¡ 2013-10-04 20:31:57
ºìÖÛÁ÷ÐÇ: ½ð±Ò+1, »¶Ó­À´ÉúÎï²ÄÁϰå¿éÓ¦Öú½»Á÷ 2013-10-08 22:32:55
ÒýÓûØÌû:
6Â¥: Originally posted by dinghuachen at 2013-10-04 15:51:53
·Ç³£¸ÐлÄãÌṩµÄÎÄÕ£¬²»¹ýÎÒ»¹ÊÇÓÐÈçÏÂÒɻ󣬼ÈÈ»ÄÉÃ×ÔØÌåÔÚÎü¸½µ°°×ºó¸üÈÝÒ×±»ÍÌÊÉ£¨µ°°×ÉÏÃæ¿Ï¶¨ÓÐÌØ¶¨°Ðµã¸ú¾ÞÊÉϸ°û±íÃæÊÜÌå×÷Óã©£¬ÎªºÎѪ½¬µ°°××ÔÉí²»»áÎü¸½µ½¾ÞÊÉϸ°û±íÃæÈ»ºó±»ÄÚÍÌÄØ£¿...

The other way round. Probably the difference depends on the signalling pathways.
The plasma protein may have CD47 containing self-peptide or molecules with similar functions, and CD47 could negotiate with the phagocyte receptor CD172a, thus to realize the ''self passivation'' and keep these proteins safe.
In contrary, proteins or particulates without CD47 would induce phagocytic activation and finally engulfed by phagocytes.
¹ØÓÚѪ½¬µ°°×£¡
Signalling pathways, Copyright-Science Magzine

[ Last edited by aircraftvip on 2013-10-4 at 18:22 ]
7Â¥2013-10-04 18:19:51
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

dinghuachen

Ìú¸Ëľ³æ (ÕýʽдÊÖ)


ÄÚÈÝÒÑɾ³ý
8Â¥2013-10-04 20:33:23
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ dinghuachen µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 070300»¯Ñ§Ñ§Ë¶311·ÖÇóµ÷¼Á +17 Áº¸»¹óÏÕÖÐÇó 2026-04-04 18/900 2026-04-08 22:53 by may_ÐÂÓî
[¿¼ÑÐ] Ò»Ö¾Ô¸211£¬0703»¯Ñ§305·ÖÇóµ÷¼Á +20 ÑÏÎ÷Î÷Ï· 2026-04-06 26/1300 2026-04-08 22:12 by ¿­¿­Òª±ä˧
[¿¼ÑÐ] 327Çóµ÷¼Á +12 Xxjc1107. 2026-04-06 12/600 2026-04-08 16:46 by luoyongfeng
[¿¼ÑÐ] 304Çóµ÷¼Á£¨085602£¬¹ýËļ¶£¬Ò»Ö¾Ô¸985£© +25 »¯¹¤ÈË999 2026-04-04 26/1300 2026-04-07 22:06 by hemengdong
[¿¼ÑÐ] ÉúÎ﹤³ÌÇóµ÷¼Á +13 ϲ»¶»¹ÊDz»¸ÊÐÄ 2026-04-05 13/650 2026-04-07 16:55 by Ecowxq666£¡
[¿¼ÑÐ] 085404 293Çóµ÷¼Á +8 ÓÂÔ¶¿â°®314 2026-04-06 9/450 2026-04-07 13:05 by flydream1314
[¿¼ÑÐ] 085405Èí¼þ¹¤³Ì301·ÖÇóµ÷¼Á£¬×¨Ë¶¿É¿çרҵ£¬ËÄÁù¼¶Òѹý +3 ¾²¾²ÏëÏë 2026-04-05 3/150 2026-04-06 15:23 by nepu_uu
[¿¼ÑÐ] 0854Çóµ÷¼Á +4 assdll 2026-04-05 4/200 2026-04-06 12:29 by ÖзÉÔº¿Õ¹ÜѧԺÑ
[¿¼ÑÐ] Ò»Ö¾Ô¸Î人Àí¹¤´óѧ080200»úе¹¤³Ì308·Ö£¬Çóµ÷¼Á +4 ÖÕ²»ËÆ´Óǰ 2026-04-05 4/200 2026-04-06 11:46 by ¿¼ÑÐѧУÕеãÈË
[¿¼ÑÐ] »¯Ñ§357·Ö£¬¿¼Ñе÷¼Á +11 .Starry. 2026-04-04 12/600 2026-04-06 06:28 by houyaoxu
[¿¼ÑÐ] 308Çóµ÷¼Á +3 ÖÕ²»ËÆ´Óǰ 2026-04-05 3/150 2026-04-05 22:23 by hemengdong
[¿¼ÑÐ] 277Çóµ÷¼Á +5 ¿¼Ñе÷¼Álxh 2026-04-05 5/250 2026-04-05 19:03 by chy09050039
[¿¼ÑÐ] ¿¼Ñе÷¼ÁÉúѰÕÒµ¼Ê¦ +3 ¹ËÕ°¿¼Ñа¡ 2026-04-05 3/150 2026-04-05 18:18 by à£à£à£0119
[¿¼ÑÐ] 295Çóµ÷¼Á +8 FZAC123 2026-04-03 8/400 2026-04-05 17:46 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 085600µ÷¼Á +9 ¶«ÕÕÕÕÕÕ 2026-04-04 9/450 2026-04-05 13:44 by ujn_zhuj
[¿¼ÑÐ] Ò»Ö¾Ô¸Î÷±±Å©ÁÖÐóÄÁר˶336·ÖÇóµ÷¼Á +3 5ourr 2026-04-03 3/150 2026-04-05 10:40 by JOKER0401
[¿¼ÑÐ] [µ÷¼ÁÐÅÏ¢]085408¹âµçÐÅÏ¢ Çóµ÷¼Á ×Ü·Ö291·ÖÊýÒ»Ó¢Ò» +3 iz11az 2026-04-02 3/150 2026-04-04 19:09 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 334Çóµ÷¼Á +8 ÔøÑöÖ® 2026-04-03 8/400 2026-04-04 11:16 by w_xuqing
[¿¼ÑÐ] ²ÄÁÏרҵ383Çóµ÷¼Á +8 ¹ùÑôÑôÑô³É 2026-04-03 8/400 2026-04-04 10:29 by Rednal.
[¿¼ÑÐ] 313Çóµ÷¼Á +3 ¡«Î¢Î¢Á¹¡« 2026-04-03 3/150 2026-04-03 11:25 by à£à£à£0119
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û