project 1: from biobased sugar platforms towards new spirocycles or cylopenta--indoles : intra or intermolecular aza-piancatelli reactions in action.
supervisors: dr. sylvie moebs-sanchez (sylvie.moebs@insa-lyon.fr) and prof. florence popowycz (florence.popowycz@insa-lyon.fr)
biobased sugar platforms such as furfural or 5-hydroxymethylfurfural (hmf) are privileged candidates as primary renewable  building blocks, readily available from fructose, glucose, sucrose, cellulose and inulin. bifunctional hmf specially features an interesting intrinsic chemical potential. to supplement previous and current investigations toward the development of different reactions from biobased products, among hmf, the proposed phd project will focus on exploring the synthesis of new azaspirocycles resulting from an intramolecular aza-piancatelli reaction of new substrates prepared from hmf but also the possibility of an original synthesis of cyclopentaindole derivatives with potential bioactive properties via an intermolecular azapiancatelli/ c-c coupling reactions sequence. multi-step synthesis of novative intermediates, development of asymmetric organocatalyzed reactions and further elaboration of complex heterocycles will be the challenging promises of this project.

project 2: toward the direct synthesis of novel sorbitan-based amines via the borrowing hydrogen methodology
supervisors: prof. maïwenn jacolot (maiwenn.jacolot@insa-lyon.fr) and florence popowycz (florence.popowycz@insa-lyon.fr)  
in the context of transition from petroleum to biorenewable resources, valorization of biomass such as starch and cellulose represents an interesting opportunity for the production of new highly functionalized “low-volume, high-value chemicals”. among all bio-based chemicals, sorbitol is a promising platform molecule. sorbitol can indeed be converted to 1,4-d-sorbitan and isosorbide respectively by single and double dehydration. contrary to isosorbide, d-sorbitan is yet underexploited in fine chemistry and its functionalization deals mainly with the synthesis of sorbitan esters or ethers. to our knowledge, the amination of sorbitan has not been reported, and could be an efficient route to accede novel bio-based amines (biosurfactants, biologically active molecules, etc.). thus, the main objective of this project is to develop the synthesis of novel sorbitan-based amines using the sustainable borrowing hydrogen methodology.

deadline for applications is october 15, 2021

for more details and application process, please go to the link: https://www-csc.utt.fr/propositions2022.htm

any interested candidates are strongly suggested to make contact with the supervisors as early as possible.

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