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药学院研究生院课程简介: https://dept.woosuk.ac.kr/chines ... ?sMenu=C1100#page12

0. 招募期间与联系方式
2021. 5 ~ 2021.6

Professor Chae 蔡教授邮箱: yjchae@woosuk.ac.kr
Email in English

1.研究方向
- Pharmacokinetics/Biopharmaceutics
- Pharmacokinetic-based drug interactions (e.g., drug transporters, drug metabolizing enzymes)
- Model based approach to predict pharmacokinetic profiles and interactions
- Investigation on transporter/metabolizing enzyme-mediated pharmacokinetic alterations in disease model and prediction of their clinical implications (e.g., inflammatory bowel disease)

2. 主要实验内容
- Cell culture (e.g., immortalized cell lines, primary hepatocytes)
- In vivo experiments using mouse/rat
- Quantitative RT-PCR, drug transport study, plasma protein binding study, microsomal stability
- Quantitative analysis: HPLC, etc.

3. 最近发表论文
Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells
YJ Chae, MS Kim, SJ Chung, MK Lee, KR Lee, HJ Maeng
Pharmaceutics 13 (2), 181

Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats
YK Song, YH Seol, MJ Kim, JW Jeong, HI Choi, SW Lee, YJ Chae, S Ahn, ...
Pharmaceutics 13 (3), 373

Development and validation of an LC-MS/MS method for monitoring larotrectinib, a tropomyosin-related kinase inhibitor, in mouse and human plasma and application to …
YJ Chae, YK Song, SH Chae, MJ Kim, JS Kang, JY Lee, TS Koo, KR Lee
Journal of Analytical Science and Technology 11, 1-9

Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse
YJ Chae, JS Song, JH Ahn, MA Bae, KR Lee
Xenobiotica 49 (7), 823-832

Feasibility of the functional expression of the human organic anion transporting polypeptide 1B1 (OATP1B1) and its genetic variant 521T/C in the mouse liver
YJ Chae, KR Lee, JH Lee, W Lee, DD Kim, SJ Chung, HJ Maeng
European Journal of Pharmaceutical Sciences 96, 28-36

Vitamin D receptor-mediated upregulation of CYP3A4 and MDR1 by quercetin in Caco-2 cells
YJ Chae, KH Cho, IS Yoon, CK Noh, HJ Lee, Y Park, E Ji, MD Seo, ...
Planta medica 82 (01/02), 121-130 返回小木虫查看更多