驴脦脤芒脳茅鲁陇录貌陆茅

麓垄脕猫虏漏脢驴2012脛锚卤戮驴脝卤脧脪碌脫脷脰脨鹿煤驴脝脩搂录录脢玫麓贸脩搂禄炉脩搂脧碌拢卢2017脛锚脫脷脣鹿驴脣脌茂脝脮脣鹿脩脨戮驴脣霉禄帽碌脙禄炉脩搂虏漏脢驴脩搂脦禄隆拢虏漏脢驴脝脷录盲脢娄麓脫脰酶脙没脫脨禄煤禄炉脩搂录脪Jin-Quan Yu陆脤脢脷拢卢麓脫脢脗卯脵麓脽禄炉脤录脟芒录眉禄卯禄炉路麓脫娄碌脛脩脨戮驴隆拢脥卢脛锚7脭脗禄帽碌脙Brown-Coxe虏漏脢驴潞贸陆卤脩搂陆冒虏垄录脫脠毛脪庐脗鲁麓贸脩搂驴陋脢录禄炉脩搂脡煤脦茂脩搂脩脨戮驴拢卢潞脧脳梅碌录脢娄脦陋脙脌鹿煤鹿煤录脪驴脝脩搂脭潞录掳脪脮脢玫驴脝脩搂脭潞脭潞脢驴Alanna Schepartz陆脤脢脷潞脥Derek Toomre陆脤脢脷隆拢脭脷麓脣脝脷录盲路垄脮鹿脕脣禄霉脫脷脨隆路脰脳脫脤陆脮毛碌脛露脿脡芦隆垄鲁陇脢卤录盲隆垄鲁卢赂脽路脰卤忙禄卯脧赂掳没脫芦鹿芒鲁脡脧帽录录脢玫隆拢脣没脫脷2019脛锚录脫脠毛PROTAC脕矛脫貌麓麓脢录脠脣Craig Crews陆脤脢脷驴脦脤芒脳茅麓脫脢脗禄炉脩搂脡煤脦茂脩搂录掳脪漏脦茂禄炉脩搂脩脨戮驴隆拢脭脷麓脣脝脷录盲脡猫录脝虏垄潞脧鲁脡脕脣脢脳赂枚脛脺鹿禄陆碌陆芒脰脗掳漏碌掳掳脳KRAS碌脛碌掳掳脳陆碌陆芒掳脨脧貌脟露潞脧脤氓 (PROTAC)隆拢脝盲脩脨戮驴鲁脡鹿没路垄卤铆脫脷Science, Nature Chemistry, Nature Communications碌脠脭脫脰戮拢卢脳脺脪媒脫脙脢媒鲁卢脟搂麓脦隆拢麓垄脕猫虏漏脢驴脫脷2021脛锚3脭脗录脫脠毛脟氓禄陋麓贸脩搂脪漏脩搂脭潞驴陋脮鹿露脌脕垄脩脨戮驴拢卢脩脨戮驴路陆脧貌脦陋禄炉脩搂脡煤脦茂脩搂拢卢脨脗脪漏脩脨路垄录掳脨脗脨脥脡煤脦茂鲁脡脧帽录录脢玫碌脛驴陋路垄隆拢

驴脦脤芒脳茅脰梅脪鲁拢潞chu-lab.org
www.sps.tsinghua.edu.cn/cn/team/team/2021/0323/110.html
脕陋脧碌路陆脢陆拢潞lingchu@mail.tsinghua.edu.cn

脪貌驴脦脤芒路垄脮鹿脨猫脟贸拢卢驴脦脤芒脳茅脮脨脝赂戮脽脫脨脫脨禄煤潞脧鲁脡禄貌陆冒脢么麓脽禄炉脨脗路麓脫娄驴陋路垄脧脿鹿脴戮颅脩茅碌脛虏漏脢驴潞贸2-3脙没拢卢脰梅脪陋麓脫脢脗脨脗脨脥脡煤脦茂脮媒陆禄路麓脫娄碌脛驴陋路垄脪脭录掳脨隆路脰脳脫脫芦鹿芒脤陆脮毛碌脛驴陋路垄碌脠鹿陇脳梅隆拢

脮脨脝赂脪陋脟贸

1. 路没潞脧脟氓禄陋麓贸脩搂虏漏脢驴潞贸脮脨脢脮脤玫录镁拢禄
2. 脪脩戮颅禄貌脮脽录麓陆芦脭脷SCI脝脷驴炉脪脭碌脷脪禄脳梅脮脽路垄卤铆脗脹脦脛拢卢脛脺鹿禄露脌脕垄驴陋脮鹿驴脝脩脨鹿陇脳梅拢禄
3. 戮脽脫脨脫脨禄煤禄炉脩搂隆垄脪漏脦茂禄炉脩搂碌脠脧脿鹿脴脩脨戮驴卤鲁戮掳拢禄
4. 脫脨鹿媒露脡陆冒脢么麓脽禄炉路麓脫娄脧脿鹿脴脩脨戮驴戮颅脩茅脮脽脫脜脧脠拢禄
5. 戮脽脫脨赂脽露脠碌脛脭冒脠脦脨脛潞脥脡脧陆酶脨脛拢卢鹿陇脳梅禄媒录芦脰梅露炉拢卢露脭驴脝脩脨脫脨脜篓潞帽碌脛脨脣脠陇拢禄
6. 戮脽卤赂露脌脕垄驴脝脩脨鹿陇脳梅脛脺脕娄脫毛脕录潞脙碌脛驴脝录录脫垄脦脛露脕脨麓脛脺脕娄隆拢

虏漏脢驴潞贸脡锚脟毛虏脛脕脧拢潞脧锚脧赂赂枚脠脣录貌脌煤拢卢脩脨戮驴戮颅脌煤脳脺陆谩碌脠脰陇脙梅鹿陇脳梅潞脥驴脝脩脨脛脺脕娄碌脛碌莽脳脫掳忙脦脛录镁隆拢


赂脷脦禄麓媒脫枚

1拢卢赂脷脦禄麓媒脫枚掳麓脮脮脟氓禄陋麓贸脩搂脧脿鹿脴鹿忙露篓脰麓脨脨隆拢驴脦脤芒脳茅陆芦赂霉戮脻鹿陇脳梅脟茅驴枚脤谩鹿漏脪禄露篓脡煤禄卯虏鹿脰煤潞脥录篓脨搂陆卤脌酶隆拢脛锚脨陆虏禄碌脥脫脷25脥貌隆拢脕铆脥芒拢卢赂霉戮脻卤戮碌楼脦禄脧脿鹿脴鹿忙露篓拢卢虏漏脢驴潞贸脪脭碌脷脪禄脳梅脮脽隆垄脟氓禄陋麓贸脩搂脦陋碌脷脪禄碌楼脦禄路垄卤铆赂脽脣庐脝陆脩搂脢玫脝脷驴炉驴脡禄帽碌脙脫脨路脟鲁拢脫脨戮潞脮霉脕娄碌脛录篓脨搂陆卤脌酶拢篓https://postdoctor.tsinghua.edu.cn/拢漏拢禄
2拢卢禄媒录芦脰搂鲁脰脤玫录镁脫脜脨茫脮脽脡锚脟毛鹿煤录脪隆掳虏漏脨脗录脝禄庐隆卤隆垄脟氓禄陋麓贸脩搂隆掳脣庐脛戮脩搂脮脽隆卤录脝禄庐
拢篓https://postdoctor.tsinghua.edu.cn/thu/index.htm拢漏脪脭录掳脝盲脣没露脿脰脰脟氓禄陋麓贸脩搂虏漏脢驴潞贸脰搂鲁脰录脝禄庐隆拢脳脢脰煤露卯露脠脳卯赂脽40脥貌脭陋拢卢脕铆脫脨露脿脧卯赂拢脌没卤拢脮脧拢禄
3拢卢脟氓禄陋麓贸脩搂脤谩鹿漏驴脡脳芒脳隆碌脛虏漏脢驴潞贸鹿芦脭垄拢篓禄貌陆脧脦陋脫脜脭陆碌脛脳芒路驴虏鹿脤霉拢漏虏垄陆芒戮枚脳脫脜庐脠毛脭掳隆垄脠毛脩搂拢禄脧铆脢脺脟氓禄陋麓贸脩搂陆脤脰掳鹿陇脡莽禄谩卤拢脧脮隆垄脳隆路驴鹿芦禄媒陆冒碌脠麓媒脫枚拢禄脧铆脢脺脠芦鹿煤虏漏鹿脺禄谩鹿脴脫脷鲁枚脮戮虏漏脢驴潞贸禄搂驴脷脟篓脪脝录掳录脪脢么禄搂驴脷脣忙脟篓碌脠脮镁虏脽拢禄
4拢卢脰搂鲁脰虏漏脢驴潞贸禄霉陆冒潞脥脳脭脠禄驴脝脩搂禄霉陆冒脡锚脟毛拢禄露脭卤铆脧脰鲁枚陆脧脟驴驴脝脩脨脟卤脕娄虏垄脫脨脪芒录脤脨酶麓脫脢脗驴脝脩脨鹿陇脳梅碌脛虏漏脢驴潞贸拢卢鹿脴脳垄虏垄禄媒录芦脨颅脰煤脝盲驴脝脩脨脰掳脪碌路垄脮鹿潞脥鹿忙禄庐隆拢

脡锚脟毛路陆脢陆
脟毛陆芦脧脿鹿脴碌莽脳脫掳忙pdf脡锚脟毛虏脛脕脧路垄脣脥脰脕lingchu@mail.tsinghua.edu.cn隆拢脫脢录镁卤锚脤芒脟毛脳垄脙梅隆掳脫娄脝赂虏漏脢驴潞贸+脨脮脙没隆卤隆拢潞脧脢脢脮脽拢卢陆芦戮隆驴矛脕陋脧碌掳虏脜脜脙忙脢脭拢卢掳矛脌铆虏漏脢驴潞贸陆酶脮戮脢脰脨酶禄貌脟漏露漏脌脥露炉潞脧脥卢隆拢

脮脨脝赂脢卤脧脼
鲁陇脝脷脫脨脨搂

麓煤卤铆脗脹脦脛

1.        M. J. Bond†, L. Chu†, D. A. Nalawansha, K. Li, C. Crews Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs. ACS Cent. Sci. 2020, 6, 1367-1375. (†co-first author)
2.        L. Chu, J. Tyson, J. Shaw, F. Rivera-Molina, A. Koleske, A. Schepartz, and D. Toomre Two-color nanoscopy of organelles for extended times with HIDE probes. Nat. Comm. 2020, 11, 4271.
3.        Z. Jin†, L. Chu†, Y. Chen, and J.-Q. Yu Pd-Catalyzed Remote meta-C篓CH Functionalization of Phenylacetic Acids Using a Pyridine Template. Org. Lett. 2018, 20, 425-428. (†co-first author)
4.        L. Chu, M. Shang, K. Tanaka, Q. Chen, N. Pissarnitski, E. Streckfuss, and J.-Q. Yu Remote meta-C篓CH activation using a pyridine-based template: achieving site-selectivity via the recognition of distance and geometry. ACS Cent. Sci. 2015, 1, 394-399.
5.        L. Chu, K. -J. Xiao, J.-Q. Yu Room-temperature enantioselective C篓CH iodination via kinetic resolution. Science 2014, 346, 451-455.
6.        L. Chu, X. -C. Wang, C. E. Moore, A. L. Rheingold, J.-Q. Yu Pd-catalyzed enantioselective C篓CH Iodination: asymmetric synthesis of chiral diarylmethylamines. J. Am. Chem. Soc. 2013, 135, 16344-16347. 返回小木虫查看更多