巴黎11大Prof. Benoît CROUSSE课题组招收CSC合作项目学生一名

作者 chenhui0706: 来源: 小木虫 1000 20 举报帖子

给实验室的老师发一个招生广告，
在u.s. news世界大学排名榜单中，巴黎第十一大学，在2019年位列世界第30位。目前已合并为巴黎萨克雷大学，巴黎萨克雷大学在2020软科世界大学学术排名（arwu）排名全球第14名，欧陆第1名
prof. benoît crousse希望招收csc学生一位。
有兴趣的童鞋可以联系：dr benoît crousse (benoit.crousse@u-psud.fr)，pr thierry brigaud (thierry.brigaud@cyu.fr)
https://www.adum.fr/as/ed/voirpr ... _prop=32636#version

many studies of the literature allowed showing certain beneficial effects by the presence of fluoroalkyl groups in a molecule. the affinity and the metabolic pathway of a molecule can be strongly modified by the introduction of a fluoroalkyl group.[1] these effects are due to the physico-chemical properties of the fluorine atom (high electronegativity, omniphobicity/lipophilicity, size, and strength of the c-f bond). thus the consequences are as follow: - modulation the acidity/basicity (pka) of a parent compound and thus the hydrogen bonding capability, - changes in the conformation of the molecule via steric and electrostatic interactions, - modification of hydrophobicity and/or replacement of the side chains of the proteogenic amino acids. consequently the “fluorine effect” provides quite attractive opportunities in drug design as shown by the current number of fluorine-containing drugs on the market which has grown to about 35%. [2]
the role of amino acids and peptides in biological functions have been identify for a long time, nevertheless, their use as pharmaceuticals or agrochemicals still remain underexploited mainly because of their proteolytic and conformational instability. the incorporation of fluorinated amino acids in their structure is one of the strategies to improve their bioavailability, activity and stabilize their secondary structure motifs.[3] fluorinated compounds can also be used as effective probes for 19f nmr studies.[4]
among these fluorinated groups, the cf3 and the cf2h groups are very attractive. they can be considered as a lipophilic isostere of alkyls or aryls for cf3 and as a hydroxyl, amino, thiol or amide group for cf2h.
the main objective of the project is - to develop efficient enantioselective synthesis of functionalized -and β-fluorinated amino acids starting from fluorine-containing building blocks, - to develop their incorporation into peptides and - to study the structural consequences of the incorporation of these amino-acids

references:
1. s. purser, p. r. moore, s. swallow, v. gouverneur, chem. soc. rev. 2008, 37, 320╟330. c. isanbor, d.
o’hagan, j. fluorine chem. 2006, 127, 303╟319. k. muller, c. faeh, f. diederich, science 2007, 317, 1881╟
1886. f. m. d. ismail, j. fluorine chem. 2002, 118, 27╟33. j.-p. bégué, d. bonnet-delpon, j. fluorine chem.
2006, 127, 992╟1012. k. kirk, curr. top. med. chem. 2006, 6, 1447╟1456. w. k. hagmann, j. med. chem.
2008, 51, 4359╟4369. i. ojima, j. org. chem. 2013, 78, 6358╟6383. j. wang, m. sanchez-rosello, j.l. acena,
c del pozo, a. e. sorochinsky, s. fustero, v. a. soloshonok, h. liu, chem. rev. 2014, 114, 2432-2506.
2. v. soloshonok et al. chem. rev. 2016, 116, 422−518.
3. a) r. smits, c. d. cadicamo, k. burger, b. koksch, chem. soc. rev. 2008, 37, 1727╟1739. b) applications
of fluorine-containing amino acids for drug design h. meia, j. hana, k. d. klikab, k. izawac, t. satoc, n. a.
meanwelld, v. a. soloshonoke eur j. med. chem. 2020, 186, 111826.
4. e. n. g. marsh, y. suzuki, acs chem. biol., 2014, 9, 1242-1250.

the candidate must have theoretical background in organic chemistry and experimental experience in synthetic organic chemistry.

level of required english: intermediate: you can speak the language in a understandable, coherent way and self-assuredly on subjects of the current life which are familiar to you.

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