捷克科学院有机化学和生物化学研究所生物分子光谱研究室招csc博士1~2名，生物分子光谱及显微拉曼成像方向，指导导师为dr. tao wu 和 prof. petr bouř

【研究方向】development of smart lanthanide-luminescence probes for biomedical raman analyses and imaging
【课题简介】
the project aims to develop a new methodology of cell imaging, by combining lanthanide-luminescence and raman microscopy. this approach overcomes a notorious problem encountered in raman imaging of small molecules whose spectroscopic signals are masked by those of other biomolecules. the probes’ emission bands will fit into the cellular‘silent’ range of the raman spectrum, thus greatly increasing ‘chemical’ contrast in the compound-specific (raman) images of living cells. compared to currently available (non-luminescent) raman tags our‘prototype’probe offers much stronger luminance, by ca two orders of magnitude. this is of course instrumental in analyzing tiny cellular structures. we will tag the probes to specific biomolecules, in order to target them to specific sites in living cells.
an important objective of the project is to design and develop efficient lanthanide probes suitable for chiral sensing of biomolecules such as proteins and nucleic acids. novel lanthanide complexes with a specific binding group will be synthesized and characterized, and their chiral spectroscopic response upon interaction with proteins and nucleic acids monitored by roa-cpl methodology.

【参考文献】
https://pubs.rsc.org/en/content/ ... 03139a#!divabstract
https://chemistry-europe.onlinel ... 1002/chem.201800840
https://onlinelibrary.wiley.com/doi/10.1002/asia.201801157
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b00435

【专业要求】光谱学、有机合成、配位化学、生物物理或生物医学相关

【研究机构背景】institute of organic chemistry and biochemistry of the czech academy of sciences (iocb prague)
https://www.uochb.cz/en

iocb prague is a leading research institution under the umbrella of the czech academy of sciences. our mission is basic research at the interface of chemical and biological sciences and translation of results from basic research into applications and commercial assets.

the biomolecular spectroscopy team employs organic synthesis, spectroscopy, and theoretical approaches to decipher the functioning of biologically relevant molecules. the overall aim is to understand the structure and properties of molecules so that we can more efficiently modify and utilize their functions. we focus on the development of novel spectroscopic techniques, theoretical procedures, and computational modelling.

【联系邮箱】 tao.wu@uochb.cas.cz
【导师情况】https://orcid.org/0000-0002-0244-3046
https://hanicka.uochb.cas.cz/~bour/

【申请截止日期】2021年2月20日

[ Last edited by huaibinwutao on 2021-1-8 at 17:35 ]

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