导师：Svetlana DOKUDOVSKAYA，联系方式：s.dokud@gmail.com，svetlana.dokudovskaya@igr.fr
申请截止日期：2021年1月3号。
博士课题
This project is focused on the uncovering the mechanisms of NPRL2-related drug resistance. Two hypothesis which might explain this phenomena would be verified: one is related to the function of NPRL2 in the DNA damage response; another one will explore the role of the NPRL2 in the connection between mitochondria quality control and mTORC1 regulation. In addition the role of other members of GATOR1 complex – proteins called NPRL3 and DEPDC5 will also be explored.
Thématique / Contexte
Living organisms have evolved various mechanisms to control their metabolism and response to various stresses, allowing them to survive and grow in different environments. In eukaryotes, the highly conserved mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cellular metabolism, proliferation and survival. A growing body of evidences indicates that mTOR signaling is closely related to another cellular protection mechanism – DNA damage response (DDR). Many factors important for DDR are also involved in the functioning of mTOR pathway.

国际交流机会
Collaboration with Rockefeller University, New York, USA
Ouverture Internationale
Participation in the international work of scientists working in mTORC1 pathway (through meetings TOR de France), autophagy (through CFATG meetings and other international meetings on autophagy), International conferences on Innovative Solutions: Cancer, Aging and Genetic diseases (ICIS).

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