湖南科技大学化学化工学院 化学工程与技术（学术型硕士）和材料与化工（专业型硕士）仍有调剂指标（学术型10名；专业型30名），欢迎化学丶化工、材料丶能化丶应化丶制药丶环境、食品、轻化、纺织等相同或相近专业考生调剂（达到A类地区国家线），并加入本人课题组。
个人简介：
万义超，男，1988年生，博士，硕士生导师，现为湖南科技大学理论有机化学与功能分子教育部重点实验室专职科研人员。主要从事基于靶点结构的药物设计、合成及生物活性研究及化学生物学的研究。近年来主持湖南省自然科学基金1项，湖南省教育厅项目1项，湖南科技大学博士科研基金1项，重点实验室开放课题1项，参与国家自然科学基金2项。在Eur. J. Med. Chem.、 Bioorg. Med. Chem.、J. Med. Chem.、Chem. Commun.、Curr. Med. Chem. 等国内外知名期刊上发表论文17篇。
教育背景
2011/09-2016/06，山东大学，药学院药物化学系，博士
2007/09-2011/06，海南大学，海洋学院制药工程，学士
联系方式：
Email: 07wanyichao@hnust.edu.cn；07wanyichao@163.com。
QQ: 385810634. Tel: 15173202737
主持或参与的科研项目：
[1] 湖南省自然科学基金：新型吲唑类Bcl-2/Mcl-1双重抑制剂的设计、合成及生物活性研究（2019JJ50145），2019.01-2021.12. (主持)
[2] 湖南省教育厅项目，新型小分子 Bcl-2/Mcl-1 双靶点抑制剂的设计、合成及生物活性研究（18C0325），2018.09-2020.12. (主持)
[3] 湖南科技大学博士科研基金，新型吲哚类衍生物的设计、合成及抗肿瘤活性研究（E51765），2018.01-2019.12. (主持)
[4] 理论有机化学与功能分子教育部重点实验室开放课题项目：新型1,3,4-噁二唑衍生物的设计、合成及抗肿瘤活性研究（E21746），2017.01-2018.12。（主持）
[5] 国家自然科学基金面上项目，新型CYP51和SDH双靶点酰胺类杀菌剂的设计合成及构效关系研究（21877034），2019.01-2022.12。（第二参与人）
[6] 国家自然科学青年基金，铜催化C-H键活化与自由基介导构筑C-C键的反应研究（21703061），2018.01-2020.12。（第一参与人）
发表的论文：
[1] Yichao Wan*, Chunxing Yan, Han Gao, Tingting Liu**, Small-molecule PROTACs: novel agents for cancer therapy. Future Medicinal Chemistry, 2020, doi: 10.4155/fmc-2019-0340.
[2] Yichao Wan*, Yuanhua Li, Chunxing Yan, Mi Yan, Zilong Tang**, Indole: A privileged scaffold for the design of anti-cancer agents, European Journal of Medicinal Chemistry, 2019, 183: 111691.
[3] Yichao Wan*, Yuanhua Li, Zhipeng Liao, Zilong Tang, Yi Li, Yunhui Zhao, Bin Xiong, A new xanthene-based fluorescent probe with a red light emission for selectively detecting glutathione and imaging in living cells, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 223:117265.
[4] Yichao Wan*, Wei Li, Zipeng Liao, Mi Yan, Xuwang Chen, Zilong Tang,  Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis, Current Medicinal Chemistry, 2019, 26:1-17.
[5] YichaoWan, Ningning Dai, ZilongTang, Hao Fang*, Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents, European Journal of Medicinal Chemistry, 2018, 146: 471-482.
[6] Yichao Wan*, Shengzhuo He, Wei Li and Zilong Tang, Indazole Derivatives: Promising Anti-tumor Agents, Anti-Cancer Agents in Medicinal Chemistry, 2018, 18(9): 1228-1234.
[7] Yichao Wan, Tingting Liu, Xiaoxian Li, Chen Chen, Hao Fang*, Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino side chains, Bioorganic & Medicinal Chemistry, 2017, 25(1): 138-152.
[8] Yichao Wan, Junhua Wang, Feng’e Sun, Minglu Chen, Xuben Hou, Hao Fang*. Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23(24), 7685-7693
[9] Yichao Wan, Shaolei Wu, Guizhi Xiao, Tingting Liu, Xuben Hou, Chen Chen, Peng Guan, Xinying Yang, Hao Fang*. Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23 (9), 1994-2003
[10] Yichao Wan, Tingting Liu, Xuben Hou, Yanyan Dun, Peng Guan and Hao Fang*. Antagonists of IAP Proteins: Novel Anti-Tumor Agents. Current Medicinal Chemistry, 2014, 21(34), 3877-3892.
[11] Tingting Liu, Yichao Wan, Yuliang Xiao, Chengcai Xia, Guiyun Duan, Dual-target inhibitors based on HDACs: Novel antitumor agents for cancer therapy, Journal of Medicinal Chemistry, 2020, doi: 10.1021/acs.jmedchem.0c00491. (本专业顶级期刊)
[12] Wei Li, Shulu Yin, Xiangyang Gong, Wang Xu, Ronghua Yang, Yichao Wan,   Lin Yuan* and XiaoBing Zhang, Achieving the ratiometric imaging of steroid sulfatase in living cells and tissues with a two-photon fluorescent probe, Chemical Communications, 2020, 56(9):1349-1352.
[13] Zilong Tang*, Xinxing Li, Yuan Yao, Yongcun Qi, Ming Wang, Ningning Dai, Yuhao Wen, Yichao Wan, Lifen Peng, Design, synthesis, fungicidal activity and molecular docking studies of novel 2-((2-hydroxyphenyl)methylamino)acetamide derivatives, Bioorganic & Medicinal Chemistry, 2019, 27 (12): 2572-2578.
[14] Renshuai Liu, Lulu Liu, Tingting Liu, Xinying Yang, Yichao Wan, Hao Fang*,
Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors, Bioorganic & Medicinal Chemistry, 2018, 26 (17): 4907-4915.
[15] Tingting Liu, Yichao Wan, Renshuai Liu, Lin Ma, Minyong Li, Hao Fang* Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors, Bioorganic & Medicinal Chemistry, 2017, 25 (6): 1939-1948.
[16] Caifang Xun, Yichao Wan, Xianyong Yu*, Lei Yang, Xiaofang Li*, Influences of urea on the interaction of 32-Norcorrole with bovine serum albumin, Spectroscopy Letters, 2017, 50 (6): 322-329.
[17] Tingting Liu, Yuqi Gao, Xiaomeng Zhang, Yichao Wan, Lupei Du, Hao Fang, Minyong Li*, Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein, Analytical Chemistry, 2017, 89 (21), 11173–11177. 返回小木虫查看更多