Thank you for submitting your manuscript "xxxxxxxxxx" to Science. I regret that we will not be able to send it out for in-depth review, and we are notifying you so that you can seek publication elsewhere.? We only publish a limited number of Perspectives, and although we do consider uninvited submissions, this particular topic is not one that we will be able to cover.? We also would not be interested in the paper in some other format. We wish you every success when you submit the paper elsewhere.

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