是药动和药代方面的文章，小修后，主编又提了以下两个问题，我有点不理解他的意思。。。请大神们帮我翻译一下，还有指点一下具体应该怎样回答比较好。。。。

Before the Editor can make the final editorial decision on your paper, he/she has requested for further revisions to be made, according to the following comments:

The authors are encouraged to resubmit after revision:

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1. State rationale of using different animal models and what are the relations in term of metabolic and pK data.

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2. The data must be explained with experimental support e.g. plasma protein binding vs molecular interaction studies.

跪谢各位了！

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