如题，二次大修，一个意见。Reviewer #1: The manuscript has improved but must still be professionally edited because many sentences are poorly constructed and/or grammatically erroneous. As an example an introduction is generally written in the present tense (instead of the past tense used by the authors), which also applies to several 'state of the art' statements in the discussion. There are also many unnecessary words and redundancies that a professional editor could remove.

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