两个审稿人，一个很看好，提了几个小问题，一个感觉很看不好，都是负面的comments，没有提出具体问题。编辑给了大修。请问大家，对于审稿人没提出具体问题，都是负面comments的应该怎么回复呢:However, the design of the experiment has no control or means to address the importance of hypoxia as a driving factor of microbial change compared other other confounding factors that are also varying among the layers at this site. The authors identify five other factors related to nutrients and pH that also differ among these layers, making it impossible to determine the cause of the differences. Furthermore, bacterial communities are not plotted showing clustering or RDA by all depths to evaluate how distinct they are.

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