饶燏实验室与魏文毅实验室招聘联合博士后开展基于蛋白质降解技术的化学生物学研究及相关转化医学研究。
应聘时间：从2019年1月起，招满为止。 招聘人数：2人
研究方向：开展基于蛋白质降解技术的化学生物学及相关转化医学研究。
关于蛋白质降解技术的研究背景,可参考饶燏教授课题组近期在Cell Research发表的研究论文:《利用新型蛋白质靶向降解技术克服Ibrutinib耐药的B细胞恶性肿瘤》PROTAC-Induced BTK Degradation as a Novel Therapy for Mutated BTK C481S Induced Ibrutinib-Resistant B-Cell Malignancies
应聘条件：
1. 对前沿药物发现，药物化学，相关生物学机制研究，药理学或转化医学工作有强烈的兴趣。
2. 博士研究背景为生物学，药理学，有机化学，药物化学，医学或相关领域。
3. 工作作风积极肯干，并有志于今后在药学及转化医学研究的学术科研领域有所发展。有良好的与人相处和沟通的能力及团队合作精神。
待遇：实验室将为博士后提供高水平的实验平台及科研环境，其它待遇按照清华大学相关规定执行（具体情况参见清华大学博士后申请相关网页）。优秀的申请人将推荐申请生命科学联合中心博士后基金。具体参见：https://www.cls.edu.cn/
联系人：饶燏 老师
申请材料：申请人的个人简历及详细的工作经历和研究成果，并提供2-3位推荐人的姓名及联系方式。请将申请材料发至：raolabthu_1@163.com
哈佛大学医学院魏文毅教授课题组研究简介：
The Wei lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School focuses on understanding how Ubiquitin E3 ligase APC (Wei et al., Nature 428: 194, 2004; Gao et at Nature Cell Biology 11: 397, 2009; Wan et al, Molecular Cell 44: 721, 2011, Wan et al, Developmental Cell 29:377, 2014) and SCF (Wei et al., Cancer Cell 8: 25, 2005; Inuzuka et al, Cancer Cell 18:147, 2010; Inuzuka et al, Nature 471:104, 2011; Gao et al, Molecular Cell 44: 290, 2011; Inuzuka et al, Cell 150(1): 179, 2012) activities contribute to cell cycle regulation and subsequent tumor formation, as well as how PTEN/Akt signaling pathway governs tumorigenesis (Liu et al, Nature 508: 541, 2014; Liu et al, Cancer Discovery 5:1194, 2015; Guo, et al, Science, 353:929; 2016). Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling, and close collaboration with the Yu Rao group at Tsinghua University to understand how PROTAC technology can achieve targeted degradation of endogenous proteins in both cell culture and animal models. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.
Detailed publications of the Wei lab can be seen at
Please also visit Wei lab at https://www.hms.harvard.edu/dms/bbs/fac/wei.php
Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and 2-3 references to Dr. Yu Rao at raolabthu_1@163.com 返回小木虫查看更多