论文返修，期刊提了几点要求，都什么意思
2.A version of the revised manuscript showing the new/changed text using track changes or highlighting. Please note that this should be uploaded as submission item "Manuscript (revision changes marked)". To facilitate further review, add line numbers in the text.
3. A clean version of the revised manuscript, also with line numbers. Please note that this should be uploaded as submission item "Manuscript".
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第2点的意思，修改版的手稿建议用修订模式（审阅菜单）进行论文修改，修改的地方会有显示，这样方便审稿人更清晰地评估你的修改稿。同时建议每行文字增加行号，便于指出论文哪一行存在问题。此外该修改版的文稿上传的时候建议命名为“手稿（修改版）”
第3点是，修改完成的稿件，同样需要添加行号，并且上传的时候命名为“手稿”。
我的理解是，审稿人需要你提交两个版本的手稿，一个是修订模式下的修改稿，方便审稿人评估你的修改过程；一个版本是修改完成稿（修订模式下点接受文档的所有修订）。
回答审稿人的问题时，可以在邮件回答审稿人问题，但建议专门给出一个文档“Response to Reviewer's Comments”，按照几个审稿人的意见，逐条进行回答。当然只是建议，你可以参考一下~
比如说下面这段话，每一行前面加行号，这样如果第5行有某个错误就可以直接指出来，一目了然。当然也不是所有期刊都要求加行号，但从你给的意见来看是需要加的。另外行号可以在word里直接设置的，你可以网上搜一下方法。
1 Mixed quantum mechanics/molecular mechanics methods offer a valuable computational tool for understanding biochemical events. When combined with
2 conformational sampling techniques, they allow for an exhaustive exploration of the enzymatic mechanism. Heme proteins are ubiquitous and essential for every3 organism. In this review we summarize our efforts towards the understanding of heme biochemistry. We present: 1) results on ligand migration on globins
4 coupled to the ligand binding event, 2) results on the localization of the spin density in compound I of cytochromes and peroxidases, 3) novel methodologies for5 mapping the electron transfer pathways and 4) novel data on Tryptophan 2,3-dioxygenase. For this enzyme our results strongly indicate that the distal oxygen
6 will end up on the C3 indole carbon, whereas the proximal oxygen will end up in the C2 position. Interestingly, the process involves the formation of an epoxide77 and a heme ferryl intermediate. The overall energy profile indicates an energy barrier of approximately 18 kcal/mol and an exothermic driving force of
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