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替朋友发个消息：
朋友受Stem Cell International (2016 SCI 3.54分)的邀请，发起组织一期干细胞和骨再生相关主题的专刊，内容从干细胞的分离，培养、鉴定，到干细胞分化调控的分子机制，以及涉及干细胞调控的生物材料均是该期特刊的收录范围，感兴趣的相关领域同仁可以关注。


Exogenous and Endogenous Stem Cells for Skeletal Regeneration
Call for Papers

Stem cell-based therapies to promote skeletal regeneration have been the focus of intensive efforts in the past decades. While important progress has been made, substantial challenges remain in the field regarding the identity and function as well as the clinical translation of stem cells. The molecular and epigenetic control of stem cell states and dynamic interactions between stem cells and the tissue microenvironment have been fundamental questions, whose answers are underpinnings for efficient clinical applications. Therapeutically, several key approaches have emerged recently, including transplantation of in vitro cultured stem cells or reconstituted tissues, as well as homing and reprogramming of native stem cells. Although skeletal regeneration mediated by exogenous stem cells have been promising, the approach is confined by limitations including insufficient homing of stem cells to repair site, low efficiency of stem cell engraftment, and reduced differentiation of stem cells in vivo. To overcome these challenges, many strategies have been developed to enhance transplanted stem cell homing, engraftment, and differentiation. Alternatively, exciting strategies have been developed to target endogenous stem cells to reprogram their lineage commitment and improve their regeneration potentials.

To highlight the tremendous advances taking place in the field, this special issue aims to discuss new strategies for circumventing the hurdles in skeletal regeneration by exploiting exogenous and endogenous stem cells. Therefore, we welcome original research articles as well as review articles.

Potential topics include but are not limited to the following:

Identification and characterization of novel stem/progenitor cell populations in skeletal tissues
Molecular and epigenetic mechanisms governing skeletal stem cell self-renewal and differentiation
Dynamic interactions between stem/progenitor cells with tissue niche and microenvironment
Novel growth factors, small molecules, or antibodies targeting native/endogenous stem cells for treatment of skeletal disorders
Novel approaches to enhance cells homing of stem/progenitor cells to the injured site and promote skeleton regeneration
Novel biomaterial/scaffolds that enhance skeletal tissue repair and regeneration
Authors can submit their manuscripts through the Manuscript Tracking System at  返回小木虫查看更多