The reason for this decision is:
The content of this manuscript does not meet the standards of rigor required by the journal to be considered for publication.

Given that 2 appointed reviewers ad the associate editor failed to support the manuscript after the review and response of the authors, I am particularly concerned about the quality of this paper. The 3rd remaining reviewer is also not convinced about the results and the authors did only partially respond to the raised issues.

第三个审稿人意见This manuscript needs a major rewrite, with particular focus on the introduction and discussion. The authors need to present a coherent story, and clearly connect their results with those that have been presented in previous studies.这是我的第一篇sci，没经验，以前投国内期刊，都没有大改过。这个意见我只是简单修改，没有按照要求大修，因为我感觉写的还可以。
但是我觉得这个主编很好的，是不是我错过机会了，我想争取下，已经给这个编辑发邀请短信咨询了，可是没回复我，是不是没机会了。
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