Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus.
作者:Ning, Hui; Tao, Hong; Weng, Zhanping; Zhao, Xingbo
Acta diabetologica
卷:53 期:6 页:891-898
出版年:2016-Dec (Epub 2016 May 05)
摘要
AIMS: Fatty acid-binding protein 4 (FABP4) is mainly expressed in adipocytes and macrophages and is demonstrated to be elevated in diabetes patients. The aim of this study was to evaluate the possible role of FABP4 in the diagnosis of GDM and to investigate the relationship between FABP4 and overweight, insulin resistance and inflammatory marker TNF-alpha.

METHODS: A total of 46 women with GDM and 55 age-matched pregnant women without GDM (non-GDM) were eligible for the study. Demographic and biochemical parameters and fasting venous blood samples of two groups were collected from all cases. Serum concentrations of FABP4 were determined using enzyme-linked immunosorbent assay (ELISA). The predictive value of Serum FABP4 level was evaluated using receiver operating characteristic curve (ROC curve) analysis.

RESULTS: We found that the serum FABP4 levels were significantly higher in GDM compared to the non-GDM group. The area under the ROC curve assay yielded a satisfactory result of 0.94 (95% confidence interval 0.90-0.98; p<0.001). The best compromise between 86.96% specificity and 89.09% sensitivity was obtained with a cutoff value of 1.96ng/mL for GDM diagnosis. Moreover, a significant positive correlation was observed between FABP4 and overweight, insulin resistance and TNF-alpha in pregnant women with GDM.

CONCLUSIONS: These results suggest that serum FABP4 may potentially serve as a novel biomarker for the prediction of GDM.
关键词
关键词列表:Fatty acid-binding protein 4; Gestational diabetes mellitus; Overweight; TNF-alpha
作者信息
地址epartment of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250012, Shandong, China.
文献信息
文献类型:Journal Article
语种:English
PubMed ID:27147422
NLM 唯一 ID:9200299
创建日期: 05 May 2016          修订日期: 18 Nov 2016
电子出版:05 May 2016
国家/地区: Germany
ISSN:1432-5233
其他信息
状态:In-Data-Review，

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