是招物理博士吗

有机化学，药物化学或化学生物学，不好意思没有写明！

Research Topic for the ParisTech/CSC PhD Program
Subfield: Organic chemistry
ParisTech School: Ecole Polytechnique
Title: Combining biomimetic and diversity-oriented strategies to synthesize natural products and medicinally relevant analogues in the aurachin series
Advisor(s):
Dr. Bastien Nay, bastien.nay@polytechnique.edu, https://naygroup.wordpress.com/
Short description of possible research topics for a PhD:
In 2013 we described the first total synthesis of aurachin D and analogues, and found potent inhibitory properties on the mitochondrial respiratory chain.1 Based on Müller's biosynthetic hypotheses, we also investigated the reactivity of our aurachin analogues in the presence of one of the aurachin biosynthetic enzymes, leading to new biosynthetic hypotheses involving a cascade of retro-[2,3]Wittig and Claisen rearrangements instead of the originally suggested pinacol rearrangement.2 Based on these findings, this PhD project aims at developing bio-inspired strategies to synthesize aurachins B and C. Diversity-oriented and function-oriented strategies will be applied in order to (1) build a medicinally relevant library of compounds and test it on relevant biological targets, and (2) simplify the aurachin core to the essential elements for biological activities (e.g. a shorter geranyl derivative has the same activity as the original farnesyl). In addition, a final level of diversity (and complexity) will be obtained through bio-inspired photooxygenated processes currently developed in our group. Overall the methodological aspects of organic synthesis will gain from our biosynthetic hypothesis to be synthetically challenged, since unprecedented chemical rearrangements (i.e. retro-[2,3]Wittig) with potentially high impact are expected to be unveiled by this work.
Required background of the student: The PhD applicant should have a Master degree in organic chemistry and a strong interest in organic synthesis and synthetic methodologies. A high level of spoken and written English is also expected. An interest in biosynthetic pathways and chemical biology would be appreciated.

该招聘信息今年继续有效！请直接联系Bastien Nay 研究员：bastien.nay@polytechnique.edu

Dear Colleagues,

ParisTech and the China Scholarship Council (CSC) have signed in 2011 an agreement to create a PhD program in France. Since the implementation of the program in 2013, 86 students have been admitted in the program.

We believe this program could be a very useful tool to further develop research cooperation between research groups in your University and ParisTech laboratories, especially through the set-up of co-supervised PhDs.

This program is open to highly qualified Chinese students interested in carrying out a PhD at ParisTech with financial support from CSC.

Please note two additions to the program since last year:
- Students have now the possibility to complete a co-supervised PhD in collaboration between their home research group in China and a host laboratory in France.
- Chinese nationals currently studying in China, but also in France or in one of the 32 partner countries, are eligible for the program.

For the 2018 admission campaign, 144 PhD Research Projects are offered by ParisTech “Grandes Ecoles” laboratories in the following Research Fields:
- Biology, Biophysics and Bio Chemistry
- Chemistry, Physical Chemistry and Chemical Engineering
- Economics, Management and Social Sciences
- Energy, Processes
- Environment Science and Technology, Sustainable Development, Geosciences
- Information and Communication Sciences and Technologies
- Life and Health Science and Technology
- Materials Science, Mechanics, Fluids
- Mathematics and their applications
- Physics, Optics
- Design, Industrialization
- Life Science and Engineering for Agriculture, Food and the Environment
- Urban planning, Transport

Candidates can apply either:
- for up to 3 PhD Research Projects listed
- or for an entire Research Field

ParisTech-CSC doctoral program - 2018 calendar and application procedure:
https://paristech-china.com/cont ... scholarship-council

List of PhD Offers:
https://paristech-china.com/content/phd-research-projects-2018，

今年截止日期是12月15号

简历请直接投至其邮箱，每年长期有效：bastien.nay@polytechnique.edu