主要研究方向: 1)肿瘤发生中肿瘤细胞和免疫系统相互作用的细胞分子机制；2）细胞转化和肿瘤发生、进展的分子基础，关注细胞转化中衰老逃逸的机制、肿瘤相关蛋白的泛素化-去泛素化失衡的生物学效应等。研究目标于发现肿瘤发生的新机制、建立可干预肿瘤发生、发展的新靶点、新策略。
项目主要涉及去泛素化酶、转录因子等在细胞转化、衰老逃逸、肿瘤免疫耐受、调节性T细胞发育的作用。相关文章发表在Nature communications, Nature Immunology, Hepatology, Eur J Immunol等杂志。

招生单位： 上海交通大学医学院（仁济医院/上海市肿瘤研究所）；课题组网址：https://www.shsci.org/newslist.aspx?id=136     联系电邮： liuyzg@shsci.org

近期主要文章：
1.  Boshi Wang, Aihui, Ma, Li Zhang, Wei-Lin Jin, Yu Qian, Guiqin Xu, Bijun Qiu, Zhaojuan Yang, Yun Liu, Qiang Xia, Yongzhong Liu*.   POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nature Communications. 2015 Oct 29;6:8704.
2.Guiqin Xu, Li Zhang, Aihui, Ma, Yu Qian, Yun Liu, Boshi Wang, Zhaojuan Yang, Yongzhong Liu*. SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells. Oncotarget. 2015 Oct 20;6(32):33636-47.
3. Li Zhang, Zhaojuan Yang, Aihui Ma, Yulan Qu, Suhua Xia, Dongxu Xu, Chao Ge, Bijun Qiu, Qiang Xia, Jinjun Li, Yongzhong Liu*. Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology. 2014; 59(1):178-89.
4. Li Zhang, Zhaojuan Yang , Yongzhong Liu*. GADD45 proteins: roles in cellular senescence and tumor development. Exp Biol Med (Maywood). 2014 28; 239 (7):773-778
5.  Yun Liu, Yingqian Xu, Jiabin Sun, Aihui Ma, Feng Zhang, Suhua Xia, Guiqin Xu, Yongzhong Liu*. AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-β receptor II signaling. Eur J Immunol. 2014; 44(2):521-32.
6.  Jiabin Sun, Boshi Wang, Yun Liu, Li Zhang, Aihui Ma, Zhaojuan Yang, Yuhua Ji, Yongzhong Liu*. Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression. Cancer Lett. 2014 ; 355(1):25-33.
7.  Jingyi Li†, Yun Liu†, Boshi Wang, Yingqian Xu, Aihui Ma, Feng Zhang, Chao Ge, Zhaojuan Yang, Jinjun Li, Yongzhong Liu*. Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice. Carcinogenesis. 2013; 34(9):2099-108.
8.  Yulan Qu, Li Zhang, Aihui Ma, Feng Zhang, Jingyi Li, Dongxu Xu, Zhaojuan Yang, Wenxin Qin, Yongzhong Liu*. c-MYC overexpression overrides TAK1 dependency in efficient tumorigenicity of AKT-transformed cells. Cancer Lett. 2013; 336 (2) :290-8.
9. Yongzhong Liu, Pin Zhang, Jun Li, Ashok B Kulkarni, Sylvain Perruche, WanJun Chen*. A critical function for TGF-β signaling in the development of nature regulatory T cells. Nature Immunology. 2008, 9, 632-640. 返回小木虫查看更多