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Study on Histocompatibility and Biodegradability of Polylactic Acid Gel in Rats
作者:Wang, T (Wang, Ting)[ 1 ] ; Cai, PL (Cai, Pei-Ling)[ 1 ] ; Heng, X (Heng, Xin)[ 1 ] ; Cheng, LJ (Cheng, Li-Jia)[ 1 ]
编者:Zhang, Z
PROCEEDINGS OF THE 2015 INTERNATIONAL CONFERENCE ON MATERIAL SCIENCE AND APPLICATIONS (ICMSA 2015)
丛书: APR
卷: 3  页: 597-600
出版年: 2015
会议名称
会议: International Conference on Material Science and Application (ICMSA)
会议地点: Suzhou, PEOPLES R CHINA
会议日期: JUN 13-14, 2015
摘要
Objective: To investigatethe effects on histocompatibility and biodegradability of bioabsorbablepolylacticacid (PLA) gelin rats. Methods: Longitudinal incision of 30 mm was made along the spine, and subcutaneous tissues were separated bluntly to make four subcutaneous pouches, and PLA gel of different molecular weight (5, 10 and 20 kD) was implanted into the pouches. 4, 7, 11 and 14 weeks after implantation, the samples and surrounding tissues were collected to perform HE staining; meanwhile, the samples were weighted and compared after drying. Results: There were few inflammatory cells accumulations in tissues treated with different molecular weight PLA gel. The degradation rate of 5 kD-PLA gel was faster than other groups. With increase of the molecular weight of PLA gel, the degradation rate was gradually decreased. Conclusion: Our findings indicated that PLA gel had good biocompatibility and a definite degrading effect, which could be further used in surgery.
关键词
作者关键词olylactic Acid Gel; histocompatibility; Biodegradability; Postoperative Adhesions
KeyWords Plus:IN-VIVO
作者信息
通讯作者地址: Cheng, LJ (通讯作者)
              Chengdu Univ, Sch Med & Nursing, 1 Shi Ling St,Cheng Luo Ave, Chengdu 610106, Sichuan, Peoples R China.
地址:
              [ 1 ] Chengdu Univ, Sch Med & Nursing, Chengdu 610106, Sichuan, Peoples R China
电子邮件地址:violetwt@qq.com; caipeiling@cdu.edu.cn; chenglijia@cdu.edu.cn
出版商
ATLANTIS PRESS, 29 AVENUE LAVMIERE, PARIS, 75019, FRANCE
类别 / 分类
研究方向:Materials Science
Web of Science 类别:Materials Science, Multidisciplinary
文献信息
文献类型roceedings Paper
语种:English
入藏号: WOS:000358617800109
ISBN:978-94-62520-75-2
ISSN: 2352-541X
其他信息
IDS 号: BD2AY
Web of Science 核心合集中的 "引用的参考文献": 12
Web of Science 核心合集中的 "被引频次": 0，

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