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Please find attached the comments of four reviewers who are in agreement that the manuscript could be publishable but not in it's current form. You will note that the reviewers have a number of concerns regarding experimental depth and indeed detail of analysis in some areas. I would be pleased to consider an amended draft and would suggest that your re submission be accompanied by a point-by-point letter of response to the reviewers comments and a narrative of changes. At this point I will also note that I will seek the opinions of our reviewers prior to making a final editorial decision. We would like to receive your revision as soon as possible.
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