PLEASE NOTE:
The journal would like to enrich online articles by visualising and providing details of chemical structures defined as the main chemical compounds described in BMCL articles. For this purpose, corresponding mol files文档 can be uploaded in our online submission system. Submitted mol files will be available for downloading from your online article on ScienceDirect. Elsevier will generate InChI keys from the mol files and include them in the online article, which increase the online searchability of your article. More information can be found at https://help.elsevier.com/app/answers/detail/p/7923/a_id/661. If you wish, you can submit MOL files along with your revised submission.

Please note that this journal offers a new, free service called Audio Slides: brief, webcast-style presentations that are shown next to published articles on ScienceDirect (see also https://www.elsevier.com/audioslides). If your paper is accepted for publication, you will automatically receive an invitation to create an AudioSlides presentation.

Bioorganic & Medicinal Chemistry Letters features the Interactive Plot Viewer, see: https://www.elsevier.com/interactiveplots. Interactive Plots provide easy access to the data behind plots. To include one with your article, please prepare a .csv file with your plot data and test it online at https://authortools.elsevier.com/interactiveplots/verification before submission as supplementary material.
With kind regards,
Masakatsu Shibasaki, PhD
Regional Editor
Bioorganic & Medicinal Chemistry Letters

Editor\'s Comments:
Please ensure that your revised manuscript follows the journal-specific guidelines listed below:

1. Address: If there is more than one affiliation, designate authors to institutions by using superscript上标 \'a\', \'b\', \'c\', etc.

2. Headings: Please do not use common headings, such as \'Introduction\', \'Chemistry\', or \'Conclusion\', other than \'Acknowledgments\' and \'References and Notes\'.

3. R1, R2: Use a superscript numeral for R1, R2 , etc. (not a subscript R1, R2) to designate substituents in graphic structures, tables, and text.

4. Reference Style: For proper reference style, please consult the References and Notes section of the Journal\'s Guide for Authors found at www.ees.elsevier.com/bmcl.  Note that the Journal uses a start page number only for journal articles.  For journal title abbreviations, please consult the list provided: Click on Guide for Authors; then click on Journal Title Abbreviation List.

5. X-ray coordinates:  X-ray coordinates must be deposited with the RCSB Protein Data Bank (PDB) database (or Cambridge Crystallographic Data Centre for small molecules) and the PDB (or CCDC) deposition number must be placed in the manuscript.

6. Experimental Information: All experimental information should be placed in the References and notes section as an endnote尾注 or placed in Supporting Information.

Reviewers\' 审稿人comments:

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本人第一次投稿，是个新手。请问这三条分别是什么意思啊？该怎么回复啊？这几条既不在Editor\'s Comments 也不在Reviewers\' comments 中，要不要理会呀？ 返回小木虫查看更多