I can now inform you that your manuscript has been evaluated.  As you will see from the appended and attached comments, major revision has been requested with full attention to the review reports and the ones in the attached annotated manuscript. In addition, please note that the paper needs significant edited (by a professional) and all figures should be large and clear enough for re-review or publication. Please pay attention the comments and suggestions as final decision will depend on the degree of improvement/revisions in the paper and responses provided.

When you submit your revision, please explain in a covering letter how and where the reviewers' comments have been incorporated; in addition, it would be helpful if you could indicate in a copy of the revised manuscript where changes have been made. Should you disagree with any part of the reviews, please explain why.

I hope that you will find the comments to be of use.  You should return your revised manuscript before Dec 21, 2015.

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