A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique.
作者:Li, Haiying; Ma, Lilan; Li, Xiaxia; Cui, Xin; Yang, Wenzhi; Shen, Shigang; Chen, Mingmao
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
卷:77 页:154-60
DOI:10.1016/j.ejps.2015.06.016
出版年:2015-Sep-18 (Epub 2015 Jun 17)
摘要
The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP-MU) complex powder was obtained by using lyophilization. GLMP-MU powder was characterized by Fourier transform infrared spectroscopy (FT IR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The formation of hydrogen bond between glimepiride and meglumine was confirmed by FT IR. The XRD studies indicated the amorphous state of glimepiride was appeared in the GLMP-MU. The DSC results were further confirmed GLMP-MU complex was prepared successfully. Moreover, the in vitro drug release rate of GLMP-MU powder was dramatically faster than that of glimepiride. Meanwhile, the AUC of GLMP-MU solution at an i.g./or i.v. dose of 5mg/kg in rat was significantly higher than that of the glimepiride suspensions. Together our results showed that hydrotropy technique was a simple and effective method to increase the solubility of glimepiride.
Copyright 2015 Elsevier B.V. All rights reserved.
关键词
关键词列表:Bioavailability; Complex; Glimepiride; Hydrotropy technique; Meglumine
作者信息
地址:College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.
文献信息
文献类型:Journal Article
语种:English
PubMed ID:26093052
NLM 唯一 ID:9317982
创建日期: 27 Jul 2015         
电子出版:17 Jun 2015
国家/地区: Netherlands
ISSN:1879-0720
其他信息
分主题子库:Index Medicus
状态:In-Data-Review，

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