Reviewer #1:
1. No list of abbreviations
2. Section 3.2.5 line 39 ....period compared with the control group add (Table 7).
3. Discussion is weak. The authors did not indicate how results relate to expectations and to earlier research.
4. Toxicity rating by joint FAO/WHO Expert Committee on Food Additives (WHO, 1966) can be use on discussion there many article that can be used,
5. Conclusion is mission  
6. Reference not in JEP formant

Reviewer #2:
1.        Format of abstract is OK.
2.        Full plant name(s) given: Yes.
3.        Specimen Voucher available? Not Mentioned.
4.        Language ok? : Yes.
5.        The sentence must be given in proper references
"All protocols were in accordance with the traditional Chinese medicine, natural medicine acute toxicity, and sub-chronic toxicity study guidelines (2005a and 2005b) (Wang et al., 2014a)".
"The medial lethal dose (LD50) was calculated according to the Horn's method (Li et al., 2015)".
6.        Needs to write in more clear manner in following paragraph.
"The acute toxicity study showed that single oral administration of EEAESL caused adverse effects and deaths when the dose increased up to 2.00 g/kg. The LD50 was 3.16 and 5.84 g/kg in female and male rats, respectively. The sub-chronic toxicity study showed that daily single oral administration of EEAESL induced no significant difference in food consumption at the end of both treatment and recovery periods compared with the control group. The body weight of male rats in high dose group increased slowly compared with the control group at the end of the recovery period".
7.        The graphical abstract must be clear with scope of this article.
8.        Author must be write proper abbreviation of the plant extract. Acute and sub-chronic toxicity study of the ethanol extract of Aralia elata (Miq.) Seem leaves (EEAESL) in rats
9.        Needs to write proper statements related to traditional use of this (Chinese) medicine. Why need this toxicological investigations.
10.        The keywords of this article is must be correct manner "Aralia elata (Miq.) Seem".
11.        Why author select the young leaf of Aralia elata (A. elata). And abbreviation must be write good manner.
12.        The reference LI et al., 2013 must be write correct manner.
13.        The references must be write correct manner "acute toxicity, and sub-chronic toxicity study guidelines (2005a and 2005b)".Acute toxicity and long- term toxicity study guidelines,
14.        Write the reference of Horn's method along with Li et al., 2015.
15. Animal ethics No.: must be mention in this article. 返回小木虫查看更多