Proline-Catalysed Direct Aldol Reaction of Chloroacetone and Aromatic Aldehydes
The combination of proline and an achiral triazabicyclodecene-derived guanidinium salt permits, for the first time, the direct aldol reaction of chloroacetone and aromatic aldehydes (see scheme). The resulting chlorohydrins are formed with high regio-, diastereo- and enantioselectivity. This procedure is experimentally simple and green, working without solvent, in test tubes placed inside a standard laboratory fridge without agitation or mechanical stirring.
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我晕，这是欧洲化学，简写是CEJ，EJOC是欧洲有机化学，一个是一级学科，一个是二级学科埃�
不对称合成。兄弟也发了篇EJOC，改天也贴上来show一下。