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In this manuscript, some C-30 triazole substituted betulin and betulinic acid derivatives were synthesized, and their cytotoxic activities were evaluated. As the authors mentioned, Anitimonova et al have published the synthesis work of a similar series of C-30 triazole derivatives last year. The synthetic procedure used in this manuscript was similar to that of Anitimonova¡¯s work, and the compound 5a has already been reported in the published paper. Although the reported biological activities in these two works were different from each other, and the finding of more cytotoxic analogues seems interesting, it is not very meaningful to publish this manuscript in its current form in this journal. It is recommended to supplement more works before it is accepted for publication, e.g., synthesizing more structural diversity compounds and evaluating their SARs.

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aglistone: ½ð±Ò+2, ¡ï¡ï¡ïºÜÓаïÖú 2014-09-12 10:43:38
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2Â¥2014-09-12 10:39:03
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2Â¥: Originally posted by ×Ô˽µÄè1988 at 2014-09-12 10:39:03
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Ö÷±à»ØÐÅʱÕâÑùµÄ£ºYour manuscript entitled "Synthesis and cytotoxicity of triterpenoids derived from betulin and betulinic acid via click chemistry" which you submitted to Journal of Asian Natural Products Research, has been reviewed. The reviewer comments are included at the bottom of this letter.

The reviewer(s) would like to see some revisions made to your manuscript before publication. Therefore, I invite you to respond to the reviewer(s)' comments and revise your manuscript.

When you revise your manuscript please highlight the changes you make in the manuscript by using the track changes mode in MS Word or by using bold or coloured text.

To submit the revision, log into http://mc.manuscriptcentral.com/ganp and enter your Author Centre, where you will find your manuscript title listed under "Manuscripts with Decisions." Under "Actions," click on "Create a Revision." Your manuscript number has been appended to denote a revision. Please enter your responses to the comments made by the reviewer(s) in the space provided. You can use this space to document any changes you made to the original manuscript. Please be as specific as possible in your response to the reviewer(s).

IMPORTANT:  Your original files are available to you when you upload your revised manuscript.  Please delete any redundant files before completing the submission.

Because we are trying to facilitate timely publication of manuscripts submitted to Journal of Asian Natural Products Research, your revised manuscript should be uploaded as soon as possible.  If it is not possible for you to submit your revision in a reasonable
amount of time, we may have to consider your paper as a new submission.

Once again, thank you for submitting your manuscript to Journal of Asian Natural Products Research and I look forward to receiving your revision.
3Â¥2014-09-12 13:25:40
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