| 查看: 805 | 回复: 4 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
xiaomao225新虫 (正式写手)
|
[求助]
第一句怎么翻译 已有2人参与
|
|
|
这句话怎么翻译？只翻译这句即可。TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. 不用翻译Abstract。 Abstract The aim of this study was to investigate the inhibitory effect of TSU68 [(Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid; SU6668], an inhibitor of vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor beta, and fibroblast growth factor receptor 1 (FGFR1), on colon cancer liver metastasis, and to test the hypothesis that TSU68 modulates the microenvironment in the liver before the formation of metastasis. First, we implanted the highly metastatic human colon cancer TK-4 orthotopically into the cecal walls of nude mice, followed by twice-daily administration of TSU68 (400 mg/kg/d) or vehicle. Five weeks of treatment with TSU68 significantly inhibited liver metastasis compared with the control group (P<0.001). Next, we analyzed the gene expression profile in premetastatic liver using microarrays. Microarray and quantitative reverse transcription-PCR analysis showed that mRNA levels for the chemokine CXCL1 were significantly increased in tumor-bearing mice compared with non-tumor-bearing mice. Moreover, CXCL1 expression was significantly decreased by TSU68 treatment. CXCR2 expression was detected predominantly on tumor cells in orthotopic tumors compared with ectopic tumors. The number of migrating neutrophils in premetastatic liver was significantly decreased in the TSU68-treated group (P<0.001). The amount of interleukin-12 (IL-12) p40 in the portal vein was significantly decreased by TSU68 (P=0.02). Blockade of both CXCR2 and IL-12 p40 with a neutralizing antibody significantly inhibited liver metastasis. These results suggest that the CXCL1/CXCR2 axis is important in cancer metastasis and that TSU68 may modulate the premetastatic niche in the target organ through suppression of the inflammatory response, which might be an alternative mechanism used by antiangiogenic agents. |
回复此楼» 猜你喜欢
296求调剂
已经有10人回复
-
295求调剂
已经有4人回复
-
297求调剂
已经有5人回复
-
303求调剂
已经有6人回复
-
314求调剂
已经有18人回复
-
广东省 085601 329分求调剂
已经有3人回复
-
272分材料子求调剂
已经有24人回复
-
中药学调剂 初试324
已经有3人回复
-
一志愿京区985，085401，与本科专业一致，电子信息工程，
已经有4人回复
-
284求调剂
已经有10人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- processes怎么翻译
已经有7人回复
- 这个怎么翻译啊？
已经有4人回复
- 求助这句话怎样翻译，两个by是怎么翻译？
已经有2人回复
- 请教“引证文献”怎么翻译？
已经有10人回复
- 请问川大英语复试线划定的比例是怎样的？
已经有15人回复
- 英文文献怎么翻译？
已经有10人回复
- 经常遇到一些英文单词有道之类都无法翻译，怎么破
已经有19人回复
- 请教这句话应该怎么翻译，谢谢！
已经有4人回复
- 一段英文翻译成中文 怎么断句
已经有2人回复
- ASME Fellow 怎么翻译
已经有9人回复
- Highlights字符数超了些，怎么办？
已经有27人回复
- 特级 一级 二级 怎么翻译呢
已经有9人回复
- 0.2 mM in 10 mL怎么翻译，尤其是mM是什么意思 ?
已经有11人回复
- 给国外教授写邮件的第一句话应该怎么写？
已经有6人回复
- 在药物化学中 PK profile 怎么翻译 是什么意思啊
已经有11人回复
- 中文中的短句在英文中该怎么翻译？
已经有8人回复
- 投英文文章怎么翻译的？
已经有16人回复
5楼2015-05-16 00:14:02
2楼2015-05-12 10:57:08
xiaomao225
新虫 (正式写手)
- 应助: 6 (幼儿园)
- 金币: 1716.1
- 散金: 171
- 红花: 9
- 帖子: 609
- 在线: 158.2小时
- 虫号: 3015889
- 注册: 2014-03-04
- 专业: 微生物学
3楼2015-05-13 00:36:07
4楼2015-05-13 12:10:53
