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lct515

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[交流] 大家帮忙看看有多大希望

投了篇Polymer Degradation and Stability，给的结论是Major Changes，下面是审稿意见，请各位帮忙分析一下有多大希望。
Dear Mr.***,

I have now received comments from a referee on your paper "Study on Molecular Modeling and the Difference of PC Lipase-Catalyzed Degradation of poly (butylene succinate) Copolymers Modified by Linear Monomers". They are shown below.

You will see that although the reviewers feel that your paper has some merit, they cannot recommend publication at this stage.

If you would like to prepare a revision along the lines they suggest, taking full account of or rebutting all the points made, I would be prepared to send the manuscript back to the reviewers for further comment.

To submit a revision, please go to http://ees.elsevier.com/pdst/ and login as an Author.
Your username is: ******

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Please note that we allow 60 days for the first author revision and 30 days for any additional author revisions that are required.

Yours sincerely,

Tadahisa Iwata, Ph.D.
Editor
Polymer Degradation and Stability

Reviewers' comments:

Reviewer #1: The authors studied the degradation differences of PBS-based copolymers in chloroform by simulating the degradation by Pseudomonas cepacia lipase. It was demonstrated that the degradation rate of PBS-co-HS was higher than that of PBS-co-BA, and generated more oligomers as degradation products in PBS-co-HS. Molecular docking proved that saturated linear monomers can improve the hydrophobicity of the copolymer backbone, which showed the possibility to further enhance the degradation of PBS-based copolymers. This paper contains new findings on degradation of PBS-based copolymers; however, the following questions arise on this paper.

1. Chloroform is a very useful solvent in the field of organic chemistry but it has serious environmental burden. Thus, in general, chloroform is not used in industry. I think that the goal of this study is to develop chemical recycling of PBS-based copolymers. Taking it into consideration, please mention the reason why chloroform was chosen as a solvent in this study.

2. The degradation of PBS-based copolymers in chloroform was too slow as shown in Fig. 3 even using lipase to simulate the degradation. Is there any aim to perform the slow degradation?

3. Did PC lipase keep correct protein folding in chloroform? Can the proposed docking modeling of PC lipase-substrate be justified by any data or evidence?

4. PBS-co-10%HS showed the best degradability among the copolymers tested. This copolymer would be suited for chemical recycling but the material property of this copolymer is enough for practical use? I suppose that PBS-co-10%HS is too soft to use as materials.

5. In Fig. 1, NMR chart is usually shown as high magnetic field in right hand and low magnetic field in left hand.

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