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ÎÄÕÂͶµ½ÆÚ¿¯Journal of Nanoparticle Research£¬Éó¸åÒâ¼ûÀ´ÁË£¬Éó¸åÈ˽¨ÒéСÐÞºó½ÓÊÕ£¬¿ÉÊDZ༭ÌáÁ˼¸µãÒâ¼û¾Í¾Ü¸ã£¬²¢ÇÒÏ£ÍûÄܹ»°´ÕÕÐÞ¸ÄÒâ¼ûÐÞ¸ÄÖØÍ¶¡£
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We have received the reports from our advisors on your manuscript NANO-D-14-01882R1 "Surface modification of paclitaxel-loaded nanoparticles with protamine ¡£¡£¡£¡£".

With regret, I must inform you that, based on the advice received, the Editors have decided that your manuscript cannot be accepted for publication in JJournal of Nanoparticle Research.
Below, please find the comments for your perusal.

I would like to thank you very much for forwarding your manuscript to us for consideration and wish you every success in finding an alternative place of publication.

Best regards,
Springer Journals Editorial Office
Journal of Nanoparticle Research

Comments for the Author:

Reviewer #1: Manuscript Number: NANO-D-14-01882R1

...........
..........
The manuscript can be accepted for publication in "Journal of Nanoparticle Research" after minor revision.

Editorial Comments: I agree with reviewer #1 that this is an interesting manuscript and may be suitable for publication in JNR based on your biological results. Please respond carefully to all Reviewer #1 comments/suggestions.

Unfortunately,I can not find either the structure of protamine or your protocol for conjugation of protamine to the NPs in this manuscript. Since many readers are not familiar with the reagent "protamine" it is important to provide some structural description of this material at an appropriate  place in the manuscript. Furthermore, your detailed  conjugation protocol for attaching protamine to the NPs is missing. This must be included in the experimental section before this manuscript can be further considered or accepted. Please indicate all revisions and changes in red in order to facilitate future editing.

We encourage the authors to significantly revise the manuscript as suggested above, and consider re-submitting a new manuscript for review to JNR.

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