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This manuscript presents the anticancer activities of some new secondary metabolites from plant origin. The activities are tested on four cancer cell lines and are one or two orders of magnitude lower than the activity of the chosen defence drug 5-fluorouracil. These results are interesting perse. The authors also attempt to establish some SAR by empirically  comparing their structures within the series of isolated compounds and with some reports from other authors. Although this is an ingesting preliminary insight it is just  semiquantitative and cannot be the basis for the conclusions. I ask the authors to review their conclusions accordingly and to pay attention to some other details as annotated in the pdf. As the paper contains an amount of original information similar to recently published paper in this journal I would like to advice publication after the necessary corrections are done. Please find attached the annotated manuscript
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